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CREST-2 Long-term Observational Extension Study (C2LOE Trial)

Birmingham, AL
N/A
Waitlist Available
Led By James Meschia, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
No Placebo-Only Group

Summary

The purpose of this Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial (C2LOE - ClinicalTrials.gov Identifier: NCT02089217) study is to study is to assess post-procedural efficacy of carotid endarterectomy and carotid stenting.

See full description
Eligible Conditions
  • Carotid artery stenosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Stroke

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Group I: Intensive Medical Management Group - no CEAExperimental Treatment1 Intervention
Subjects assigned to the intensive medical management alone with no carotid endarterectomy (CEA) group in the CREST-2 study (NCT02089217)
Group II: Intensive Medical Management Group - no CASExperimental Treatment1 Intervention
Subjects assigned to the intensive medical management alone with no carotid stenting (CAS) group in the CREST-2 study (NCT02089217)
Group III: Carotid Stenting Group (CAS)Experimental Treatment2 Interventions
Subjects assigned to the intensive medical management with carotid stenting group in the CREST-2 study (NCT02089217)
Group IV: Carotid Endarterectomy Group (CEA)Experimental Treatment2 Interventions
Subjects assigned to the intensive medical management with carotid endarterectomy group in the CREST-2 study (NCT02089217)

Find a Location

Closest Location:University of Alabama at Birmingham· Birmingham, AL

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,393 Previous Clinical Trials
3,202,340 Total Patients Enrolled
University of Alabama at BirminghamOTHER
1,664 Previous Clinical Trials
2,448,546 Total Patients Enrolled
Medical University of South CarolinaOTHER
986 Previous Clinical Trials
7,404,358 Total Patients Enrolled
University of MarylandOTHER
171 Previous Clinical Trials
322,793 Total Patients Enrolled
National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,390 Previous Clinical Trials
653,312 Total Patients Enrolled
James Meschia, MDPrincipal InvestigatorMayo Clinic
3 Previous Clinical Trials
5,395 Total Patients Enrolled
~692 spots leftby Feb 2026