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N/A

Memory Training for Mild Cognitive Impairment (WMTrain Trial)

N/A
Recruiting
Led By Alexandru Iordan, Ph.D.
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
MCI Diagnosis
Be older than 18 years old
Must not have
Sensory impairments that limit ability to participate
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial will test whether working memory training can help people with early memory loss.

Who is the study for?
This trial is for older adults who have been diagnosed with amnestic mild cognitive impairment (MCI). Participants must be able to undergo MRI scans, be right-handed, and not have other neurological conditions, significant mental illnesses, sensory impairments that could affect participation, or a history of substance abuse.
What is being tested?
The study is testing the effectiveness of working memory training on improving cognitive functions in individuals with MCI. It aims to see if this type of brain exercise can lead to changes in neural activity and enhance memory capabilities.
What are the potential side effects?
Since the intervention involves non-invasive cognitive exercises rather than medication or surgery, no direct physical side effects are expected. However, participants may experience fatigue or frustration during challenging tasks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with mild cognitive impairment.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I do not have sensory impairments that limit my participation.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Changes in brain activation within the WM network
Gains in WM training task performance
Secondary study objectives
Changes in criterion (fMRI) WM task performance
Changes in functional connectivity within and between canonical brain networks

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Active Control
Group I: In-Person, MCIActive Control1 Intervention
Participants diagnosed with MCI will undergo 10 sessions of WM training in person.
Group II: Online, HealthyActive Control1 Intervention
Cognitively intact older adults will undergo 10 sessions of WM training online.
Group III: Online, MCIActive Control1 Intervention
Participants diagnosed with MCI will undergo 10 sessions of WM training online.

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor
1,855 Previous Clinical Trials
6,435,031 Total Patients Enrolled
Alexandru Iordan, Ph.D.Principal InvestigatorUniversity of Michigan
Alexandru IordanPrincipal InvestigatorUniversity of Michigan
~7 spots leftby Sep 2025
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