Memory Training for Mild Cognitive Impairment (WMTrain Trial)
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Michigan
No Placebo Group
Approved in 3 jurisdictions
Trial Summary
What is the purpose of this trial?This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).
How is the Working Memory Training treatment different from other treatments for mild cognitive impairment?
Working Memory Training, specifically Cogmed, is unique because it is a computerized program designed to improve working memory through adaptive exercises, unlike other treatments that may not focus on this specific cognitive function or use technology in this way.
23459Is working memory training, like Cogmed, safe for humans?
Research on working memory training programs like Cogmed, used for various conditions including mild cognitive impairment and attention-deficit/hyperactivity disorder, does not report any safety concerns, suggesting it is generally safe for humans.
24568What data supports the effectiveness of the treatment Working Memory Training for Mild Cognitive Impairment?
Research shows that computerized working memory training, like Cogmed, can improve working memory and other cognitive functions in people with mild cognitive impairment. Some studies found improvements in memory and language processing, and reduced memory complaints in everyday activities.
12457Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
Eligibility Criteria
This trial is for older adults who have been diagnosed with amnestic mild cognitive impairment (MCI). Participants must be able to undergo MRI scans, be right-handed, and not have other neurological conditions, significant mental illnesses, sensory impairments that could affect participation, or a history of substance abuse.Inclusion Criteria
I have been diagnosed with mild cognitive impairment.
Exclusion Criteria
I do not have sensory impairments that limit my participation.
Participant Groups
The study is testing the effectiveness of working memory training on improving cognitive functions in individuals with MCI. It aims to see if this type of brain exercise can lead to changes in neural activity and enhance memory capabilities.
3Treatment groups
Active Control
Group I: In-Person, MCIActive Control1 Intervention
Participants diagnosed with MCI will undergo 10 sessions of WM training in person.
Group II: Online, HealthyActive Control1 Intervention
Cognitively intact older adults will undergo 10 sessions of WM training online.
Group III: Online, MCIActive Control1 Intervention
Participants diagnosed with MCI will undergo 10 sessions of WM training online.
Working Memory Training is already approved in European Union, United States, Canada for the following indications:
🇪🇺 Approved in European Union as Cogmed Working Memory Training for:
- Attention Deficit Hyperactivity Disorder (ADHD)
- Learning Disabilities
- Cognitive Impairment
🇺🇸 Approved in United States as Cogmed Working Memory Training for:
- ADHD
- Learning Disabilities
- Amnestic Mild Cognitive Impairment (MCI)
🇨🇦 Approved in Canada as Cogmed Working Memory Training for:
- ADHD
- Learning Disabilities
- Cognitive Impairment
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
University of MichiganAnn Arbor, MI
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Who is running the clinical trial?
University of MichiganLead Sponsor
References
A single case study of computerised cognitive training for older persons with mild cognitive impairment. [2018]The results of a multiple baseline single case study using computerised cognitive training in older adults with Amnestic Mild Cognitive Impairment (aMCI) are reported. Two participants each completed 40 sessions of training in two phases: an initial phase that trained attention, processing speed and cognitive flexibility, followed by a mixed memory and execution functions phase. It was hypothesised that participants would improve with practice on the trained tasks, that the benefits of training would generalise to non-trained neuropsychological probe measures, and that training would result in improved perceptions of memory and mood. Results indicated that one participant showed improved performance on untrained measures of attention and reasoning. On pre/post measures both participants reported less frequent cognitive failures in everyday life and improved mood following training. The results are discussed along with suggestions for future research.
Cognitive Training Program to Improve Working Memory in Older Adults with MCI. [2022]Deficits in working memory (WM) are associated with age-related decline. We report findings from a clinical trial that examined the effectiveness of Cogmed, a computerized program that trains WM. We compare this program to a Sham condition in older adults with Mild Cognitive Impairment (MCI).
A comparison of the effects between 2 computerized cognitive training programs, Bettercog and COMCOG, on elderly patients with MCI and mild dementia: A single-blind randomized controlled study. [2021]A computerized cognitive rehabilitation program can be used to treat patients with mild cognitive impairment or dementia. We developed a new computerized cognitive rehabilitation program (Bettercog) that contained various treatment programs for cognitive training for mild cognitive impairment or dementia. This study was conducted to compare the clinical efficacy of Bettercog and computer-assisted cognitive rehabilitation (COMCOG) that has had clinical efficacy previously proven in patients with mild cognitive impairment or dementia.
Adaptive Computerized Working Memory Training in Patients With Mild Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial. [2022]Label="OBJECTIVE" NlmCategory="OBJECTIVE">We investigated if a 5-week computerized adaptive working memory training program (Cogmed®) of 20 to 25 sessions would be effective in improving the working memory capacity and other neuropsychological functions compared to a non-adaptive working memory training program (active-controlled) in adult patients with mild cognitive impairment (MCI).
Cognitive Improvement in Older Adults with Mild Cognitive Impairment: Evidence from a Multi-Strategic Metamemory Training. [2020]Intervention programs to relieve memory impairment and memory-related complaints in older adults with mild cognitive impairment are needed. Objective: The purpose of the current study was to assess the efficacy of a novel cognitive training approach-named multi-strategic metamemory training-in older adults with amnestic mild cognitive impairment. Among a total of 113 older adults with mild cognitive impairment, 66 participated in the memory training program (training group) and 47 did not (control group). Repeated measures of analysis of variance revealed that compared with the control group, the training group experienced: i) a significantly greater increase in cognitive test scores of long-term delayed free recall (Finteraction = 6.04, p = .016) and fluency (Finteraction = 4.11, p = .045) and ii) significantly greater decrease in their subjective memory complaints for everyday memory (Finteraction = 7.35, p = .009). These results suggest that the training program can improve verbal memory (i.e., delayed free recall), language processing (i.e., categorical fluency) and limit complaints in everyday instrumental memory activities of mildly impaired older adults.
[Working memory training in normal and pathological aging: neurocognitive gains and generalization]. [2021]Working memory is one of the cognitive functions that is the most sensitive to normal and pathological age-related effects. In older individuals with a mild cognitive impairment, deficits in working memory are frequent and can precede those of episodic memory, in addition to having a strong prognostic value of evolution toward a dementia of Alzheimer type. Because of its implication in numerous cognitive and cognitive-motor tasks, working memory is called upon in a wide range of daily life activities. Impairment in working memory therefore increases the risk of a loss of autonomy. In the current review, we present different working memory training programs. We show how these training programs are associated with specific effects and to near and far transfers towards other cognitive functions in older adults without cognitive impairment or with mild cognitive impairment, as well as in patients with dementia. We show that the benefits are confirmed by neuronal modifications, suggesting an improvement in the neuronal efficiency of the targeted or related trained processes. Finally, we consider the central question of the generalization of the cognitive gains of working memory training toward ecological situations.
Working Memory Training in Amnestic and Non-amnestic Patients With Mild Cognitive Impairment: Preliminary Findings From Genotype Variants on Training Effects. [2021]Working memory training (WMT) effects may be modulated by mild cognitive impairment (MCI) subtypes, and variations in APOE-epsilon (APOE-ε) and LMX1A genotypes. Sixty-one individuals (41 men/20 women, mean age 66 years) diagnosed with MCI (31 amnestic/30 non-amnestic) and genotyped for APOE-ε and LMX1A completed 4 weeks/20-25 sessions of WMT. Cognitive functions were assessed before, 4 weeks and 16 weeks after WMT. Except for Processing Speed, the non-amnestic MCI group (naMCI) outperformed the amnestic MCI (aMCI) group in all cognitive domains across all time-points. At 4 weeks, working memory function improved in both groups (p < 0.0001), but at 16 weeks the effects only remained in the naMCI group. Better performance was found after training for the naMCI patients with LMX1A-AA genotype and for the APOE-ε4 carriers. Only the naMCI-APOE-ε4 group showed improved Executive Function at 16 weeks. WMT improved working memory and some non-trained cognitive functions in individuals with MCI. The naMCI group had greater training gain than aMCI group, especially in those with LMX1A-AA genotype and among APOE-ε4-carriers. Further research with larger sample sizes for the subgroups and longer follow-up evaluations is warranted.
A randomized EPIREMED protocol study on the long-term visuo spatial effects of very preterm children with a working memory deficit. [2021]Very preterm children generally perform poorly in executive functions and particularly in working memory. Adaptive training tasks encouraging these children to work continuously on their personal working memory capacity can be very useful. Above all in preschool-age children, several cognitive training programs focused on improving working memory capacity. Cogmed is a computerized visuospatial cognitive training program that improves working memory in children and adolescents with attention-deficit/hyperactivity disorder. The main objective is to assess the long-term effects (18 months) of cognitive training (Cogmed) on visuospatial processing in preschool-age very preterm children with working memory impairment.
Cortical Thickness Changes After Computerized Working Memory Training in Patients With Mild Cognitive Impairment. [2022]Adaptive computerized working memory (WM) training has shown favorable effects on cerebral cortical thickness as compared to non-adaptive training in healthy individuals. However, knowledge of WM training-related morphological changes in mild cognitive impairment (MCI) is limited.