Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET Scan for Cancer
This trial uses a radioactive antibody to help detect cancer cells in patients with high levels of a protein called CEA. PET scans may help find and diagnose cancer that may not be detected by other methods.
Radiotherapy
Contrast-Enhanced Ultrasound for Bile Duct Cancer
This trial is testing whether a type of ultrasound that uses gas microbubbles can predict how well bile duct cancer will respond to targeted radiotherapy. The ultrasound may also help doctors see if microbubble popping can improve bile duct cancer response to radiotherapy.
PARP Inhibitor
Pembrolizumab + Olaparib for Bile Duct Cancer
This trial tests a combination of two drugs, olaparib and pembrolizumab, in patients with advanced bile duct cancer who haven't responded to standard treatment. Olaparib makes it harder for cancer cells to repair themselves, while pembrolizumab helps the immune system attack the cancer. The goal is to see if this combination can improve treatment response rates and extend patient survival.
Popular Filters
Trials for Cholangiocarcinoma Patients
Enzyme Inhibitor
BAY 1895344 + Chemotherapy for Bladder Cancer
This trial tests a new drug, BAY 1895344, combined with chemotherapy to treat advanced cancers. It aims to find the best dose and check for side effects. The treatment works by blocking enzymes needed for tumor growth and killing cancer cells. The trial focuses on patients with advanced solid tumors or urothelial cancer.
Alkylating agents
Chemotherapy for Biliary Tract Cancer
This trial is testing how well two cancer-fighting drugs work together, and whether adding a third drug makes them more effective in treating patients with advanced biliary tract cancers. The drugs aim to kill cancer cells, stop them from dividing, or prevent them from spreading.
Trials for EBD Cancer Patients
Enzyme Inhibitor
BAY 1895344 + Chemotherapy for Bladder Cancer
This trial tests a new drug, BAY 1895344, combined with chemotherapy to treat advanced cancers. It aims to find the best dose and check for side effects. The treatment works by blocking enzymes needed for tumor growth and killing cancer cells. The trial focuses on patients with advanced solid tumors or urothelial cancer.
Alkylating agents
Chemotherapy for Biliary Tract Cancer
This trial is testing how well two cancer-fighting drugs work together, and whether adding a third drug makes them more effective in treating patients with advanced biliary tract cancers. The drugs aim to kill cancer cells, stop them from dividing, or prevent them from spreading.
Trials for Metastatic Patients
Monoclonal Antibodies
DB-1303 for Solid Cancers
This trial is testing a new drug called DB-1303 to see if it is safe for patients with advanced solid tumors that express HER2. The study will begin with lower doses and increase them over time to find the highest dose that patients can handle. This helps determine the best dose for future studies.
Enzyme Inhibitor
BAY 1895344 + Chemotherapy for Bladder Cancer
This trial tests a new drug, BAY 1895344, combined with chemotherapy to treat advanced cancers. It aims to find the best dose and check for side effects. The treatment works by blocking enzymes needed for tumor growth and killing cancer cells. The trial focuses on patients with advanced solid tumors or urothelial cancer.
Alkylating agents
Chemotherapy for Biliary Tract Cancer
This trial is testing how well two cancer-fighting drugs work together, and whether adding a third drug makes them more effective in treating patients with advanced biliary tract cancers. The drugs aim to kill cancer cells, stop them from dividing, or prevent them from spreading.
Phase 3 Trials
Alkylating agents
Chemotherapy for Biliary Tract Cancer
This trial is testing how well two cancer-fighting drugs work together, and whether adding a third drug makes them more effective in treating patients with advanced biliary tract cancers. The drugs aim to kill cancer cells, stop them from dividing, or prevent them from spreading.
Kinase Inhibitor
Pemigatinib vs Chemotherapy for Bile Duct Cancer
This trial is testing a new drug called pemigatinib against the usual cancer treatment. It focuses on patients with advanced bile duct cancer who have a specific change in their genes. The goal is to see if pemigatinib is more effective and safer than the usual treatment. Pemigatinib is the first of its kind approved in the US, receiving approval recently.
Monoclonal Antibodies
CTX-009 + Paclitaxel for Biliary Tract Cancer
This trial tests a new drug (CTX-009) combined with chemotherapy in patients with advanced biliary tract cancers who have already had other treatments and cannot have surgery. The treatment aims to boost the immune system and stop cancer cell growth.
Monoclonal Antibodies
Atezolizumab + Bevacizumab for Gastrointestinal Cancer
This trial will enroll 20 patients with gastrointestinal cancers who have completed all standard treatments but still have evidence of the disease. Patients will receive intravenous atezolizumab and bevacizumab once every 21 days for a maximum of 12 months.
FGFR Inhibitor
Tinengotinib for Bile Duct Cancer
This trial is testing an oral medication called Tinengotinib for patients with a specific type of bile duct cancer that has not responded to other treatments. The medication works by blocking a protein that helps cancer cells grow. The goal is to see if Tinengotinib can slow down or stop the cancer in these patients.
Trials With No Placebo
Monoclonal Antibodies
DB-1303 for Solid Cancers
This trial is testing a new drug called DB-1303 to see if it is safe for patients with advanced solid tumors that express HER2. The study will begin with lower doses and increase them over time to find the highest dose that patients can handle. This helps determine the best dose for future studies.
Enzyme Inhibitor
BAY 1895344 + Chemotherapy for Bladder Cancer
This trial tests a new drug, BAY 1895344, combined with chemotherapy to treat advanced cancers. It aims to find the best dose and check for side effects. The treatment works by blocking enzymes needed for tumor growth and killing cancer cells. The trial focuses on patients with advanced solid tumors or urothelial cancer.
View More Related Trials
Frequently Asked Questions
Introduction to bile duct cancer
What are the top hospitals conducting bile duct cancer research?
When it comes to the battle against bile duct cancer, several top hospitals are leading the charge in clinical trials. In New york City, Memorial Sloan Kettering Cancer Center stands out with five active trials dedicated to this rare and challenging disease. With a history of eight completed studies since their first recorded trial in 2000, they have been at the forefront of research for over two decades. Meanwhile, all the way in Bethesda, Maryland, the National Institutes of Health Clinical Center is also making significant strides. They currently have four active clinical trials for bile duct cancer and have been conducting these studies since 2013.
Similarly contributing to this vital research is the University of California Davis Comprehensive Cancer Center in Sacramento. With four ongoing trials focusing on bile duct cancer and a total of five completed studies dating back to their inaugural investigation in 2010, they are making an impact on understanding this complex condition.
In Columbus, Ohio State University Comprehensive Cancer Center has joined forces as well with its own set of four active clinical trials for bile duct cancer and a consistent dedication demonstrated through their previous five investigations that commenced from 2011 onwards.
Last but not least among these pioneering institutions is the City of Hope Comprehensive Cancer Center located in Duarte. This esteemed center has displayed unwavering commitment by conducting three previous bile duct cancer trials since recording their first study on this specific type of cancer back in 2014; additionally demonstrating equal dedication towards finding new treatment possibilities through participating actively within same number -four- present-day tests focused solely upon such cases.
These remarkable efforts across multiple medical centers symbolize hope for those affected by bile duct cancer while emphasizing how collaboration among experts can lead to advancements in treatment options and improved outcomes for patients globally.
Which are the best cities for bile duct cancer clinical trials?
When it comes to bile duct cancer clinical trials, several cities show promise in advancing research and treatment options. Honolulu, Hawaii, leads the way with 23 active trials investigating treatments like Arm B (pevonedistat, paclitaxel, carboplatin), Cisplatin, and DB-1303. Anchorage, Alaska follows closely behind with 16 ongoing studies focusing on Cisplatin and alternative therapies. Boston, Massachusetts also plays a significant role with 12 active trials exploring Cobimetinib, pembrolizumab, DB-1303 among others. Lastly,'Aiea in Hawaii and Houston,Texas showcase their commitment to breakthroughs by hosting eight active trials each that investigate various treatment strategies for bile duct cancer patients. These cities serve as crucial hubs for cutting-edge clinical research aiming to improve outcomes for individuals fighting this challenging disease.
Which are the top treatments for bile duct cancer being explored in clinical trials?
Clinical trials investigating potential treatments for bile duct cancer have yielded several promising options. Topping the list is tivozanib, a newcomer with two active trials and a total of two all-time studies focusing on bile duct cancer since its first listing in 2021. Cisplatin follows closely behind, also engaged in two ongoing trials and contributing to nine all-time research endeavors since being listed in 2007. Nab-paclitaxel shows similar promise with two active trials and an equal number of all-time studies dedicated to examining its efficacy against bile duct cancer after it was listed as a treatment option in 2019. Lastly, floxuridine enters the scene with one active trial and one all-time study specifically targeting bile duct cancer since its inclusion as a potential therapy began in 2022. These clinical investigations offer hope for improved outcomes for individuals battling this challenging form of cancer.
What are the most recent clinical trials for bile duct cancer?
Recent clinical trials have offered new possibilities for patients with bile duct cancer, presenting potential advancements in treatment options. One such trial is Arm A, a Phase 2 study that explores an innovative approach to tackling this type of cancer. Additionally, the combination of Gemcitabine + Cisplatin + Durvalumab + Yttrium-90 Selective Internal Radiation Therapy has shown promise as a potential therapy option in Phase 2 trials. Another Phase 2 trial investigated the efficacy of Floxuridine specifically for bile duct cancer patients. Furthermore, Nab-paclitaxel and Tivozanib have been under investigation in both Phase 1 and Phase 2 studies as potential treatments for bile duct cancer. These recent clinical trials bring renewed hope to those affected by this challenging disease.
What bile duct cancer clinical trials were recently completed?
Several clinical trials investigating potential treatments for bile duct cancer have recently concluded, offering valuable insights into the battle against this challenging disease. In October 2019, Mayo Clinic successfully completed a trial evaluating the efficacy of Trifluridine and Tipiracil Hydrochloride in combating bile duct cancer. Another notable study was conducted by Klus Pharma Inc., completing in July 2018, exploring the effectiveness of A166 therapy. Additionally, Intensity Therapeutics, Inc.'s research on INT230-6 reached completion in February 2017. These milestones highlight the commitment of researchers to finding innovative solutions for bile duct cancer patients and underline the ongoing efforts to improve treatment options for this condition.