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Comprehensive Training Program for Surgery Recovery (COPEiOS Trial)

N/A

Recruiting

Led By Christopher G Hughes, MD

Research Sponsored by Vanderbilt University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

undergoing elective major non-cardiac surgery with expected hospitalization ≥3 days

≥60 years old

Must not have

Severe frailty or physical impairment that prohibits participation in the program

Cognitively unable to consent for surgery (i.e., dementia or cognitive impairment of a severity that precludes ability to self-consent and, thus, also participation in study interventions)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months after discharge

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether a combination of computerized cognitive training and physical exercise before and after surgery can improve long-term cognitive and disability outcomes in older surgical patients.

Who is the study for?

The COPE-iOS study is for individuals aged 60 or older who are scheduled for elective major non-cardiac surgery with a hospital stay of at least 3 days. Participants must be able to consent, use a tablet or laptop, and understand English. Those with severe frailty, cognitive impairment preventing self-consent, or enrolled in similar trials cannot join.

What is being tested?

This trial tests if combining computerized brain exercises and physical training before and after surgery can improve long-term mental function and reduce disability in older patients. Half will receive the comprehensive program while the other half gets control activities like simple games and stretching.

What are the potential side effects?

Since this trial involves cognitive and physical exercises rather than medication, side effects may include typical exercise-related issues such as muscle soreness or fatigue but are expected to be minimal.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am scheduled for a major surgery that is not heart-related and will be in the hospital for 3 or more days.

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I am 60 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am too frail or physically impaired to participate in the program.

Select...

I am able to understand and consent to surgery on my own.

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My surgical team does not approve of me participating in physical activities.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day of surgery, postoperative day 2, postoperative day 5, and 3 months after discharge

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day of surgery, postoperative day 2, postoperative day 5, and 3 months after discharge

This trial's timeline: 3 weeks for screening, Varies for treatment, and day of surgery, postoperative day 2, postoperative day 5, and 3 months after discharge for reporting.