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Cardiovascular Autonomic Function and Endogenous Pain Modulation

N/A

Waitlist Available

Led By Marie Hoeger Bement, PT, PhD

Research Sponsored by Marquette University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up on session 1, 2 and 3 which are on day 1,7 and 21 of data collection

Awards & highlights

No Placebo-Only Group

Summary

This trial looks at how well patients with fibromyalgia respond to different types of pain stimuli.

Eligible Conditions

Musculoskeletal Disease
Fibromyalgia
Exercise
Pain
Autonomic Nervous System Disorders
Physical Activity

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ on session 1, 2 and 3 which are on day 1,7 and 21 of data collection

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~on session 1, 2 and 3 which are on day 1,7 and 21 of data collection

This trial's timeline: 3 weeks for screening, Varies for treatment, and on session 1, 2 and 3 which are on day 1,7 and 21 of data collection for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Foot

Change from Baseline Pressure Pain Threshold to immediately after cognitive task.

Change from Baseline Pressure Pain Threshold to immediately after performance of exercise.

+4 more

Secondary study objectives

American College of Rheumatology Diagnostic Criteria for Fibromyalgia

Baseline Fat Mass

Baseline Lean Mass

+11 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Isometric (Static) ExerciseExperimental Treatment1 Intervention

Subjects will perform isometric (static) handgrip exercise at submaximal intensity for four minutes. The exercise will be performed while the subject is seated, and the elbow bent at around 90° and unsupported. Subjects will be asked to rate their pain using numerical pain rating scale that ranges from 0 (no pain) to 10 (worst pain), perceived exertion (RPE) from 0 (Nothing at all) to 10 (extremely strong), and perceived stress from 0 (not stressed at all) to 10 (extremely stressed). The ratings of pain intensity, RPE and perceived stress will be provided before, at the middle and at the end of the exercise.

Group II: Cognitive TaskExperimental Treatment1 Intervention

The mental math task, which is also known as serial subtraction test, will be performed for four minutes. Subjects will be asked to rate their pain intensity and perceived stress before, at the middle and at the end of the mental math task.

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