What is the mechanism of action of this treatment?

Common treatments for Borderline Personality Disorder (BPD) like Dialectical Behavior Therapy (DBT) and Schema-focused therapy work by modifying dysfunctional thinking patterns and behaviors. DBT focuses on managing suicidal behaviors, improving emotional regulation, and enhancing interpersonal effectiveness. Schema-focused therapy aims to reshape deep-seated maladaptive beliefs formed in early life. Cognitive Reappraisal Training, similar to these therapies, helps patients reframe negative thoughts and emotions, which is crucial for reducing emotional dysregulation and improving overall functioning in BPD patients.

What side effects are associated with this type of intervention?

Common treatments for Borderline Personality Disorder (BPD) include Cognitive Behavioral Therapy (CBT), Dialectical Behavior Therapy (DBT), and other psychodynamic approaches. Side effects of these therapies are generally minimal compared to pharmacological treatments. However, patients may experience emotional distress during sessions as they confront challenging thoughts and behaviors. Additionally, the intensive nature of therapies like DBT, which often require weekly individual and group sessions, can be demanding and may lead to burnout or dropout if not managed properly. Overall, these therapies are considered safe and effective, with the primary 'side effects' being related to the emotional and time investment required.

What prior FDA approvals exist?

As of now, there are no FDA-approved medications specifically for the treatment of Borderline Personality Disorder (BPD). Treatment typically involves various forms of psychotherapy. Cognitive-behavioral therapies, such as Dialectical Behavior Therapy (DBT) and Schema-Focused Therapy, are commonly used and have shown efficacy in managing BPD symptoms. Cognitive Reappraisal Training, like the Reappraisal-by-Distancing approach being studied, is a novel cognitive-behavioral technique aimed at helping patients reframe their thoughts and emotional responses, which aligns with the principles of these established therapies.

What other types of research exist?

Promising, novel alternatives to Reappraisal-by-Distancing for BPD patients include Dialectical Behavior Therapy (DBT), Mentalization-Based Therapy (MBT), Transference-Focused Therapy (TFT), Good Psychiatric Management (GPM), and Schema-Focused Therapy. These therapies have shown comparable effectiveness and can be selected based on availability and patient preference.

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Cognitive Reappraisal Training for Borderline Personality Disorder (BPD Trial)

N/A

Recruiting

Led By Harold Koenigsberg, MD

Research Sponsored by Icahn School of Medicine at Mount Sinai

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Must not have

Age > 55

Timeline

Screening 3 days

Treatment Varies

Follow Up 3 days

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to test a new way of helping people with Borderline Personality Disorder (BPD) manage their emotions by teaching them to think differently about emotional events. This method, called cognitive reappraisal training, could improve their mental health and behavior.

Who is the study for?

This trial is for medically healthy adults with Borderline Personality Disorder who can provide informed consent. It's not open to individuals over 55 or those with Schizotypal Personality Disorder or Avoidant Personality Disorder, due to their distinct neural activity patterns.

What is being tested?

The study tests a new treatment approach called cognitive reappraisal training by distancing. This method could be used alone or alongside other treatments for BPD, aiming to improve emotional regulation and influence behavior.

What are the potential side effects?

Since this is a psychological training intervention rather than a drug, traditional physical side effects are not expected. However, participants may experience emotional discomfort when engaging in the exercises.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am older than 55.

Timeline

Screening ~ 3 days1 visit

Treatment ~ Varies

Follow Up ~ 3 days1 visit

Screening ~ 3 days

Treatment ~ Varies

Follow Up ~3 days

This trial's timeline: 3 days for screening, Varies for treatment, and 3 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in PINES Network activity

Change in Zanarini Rating Scale for Borderline Personality (ZAN-BPD)

Secondary study objectives

Change in Affective Lability Scale total (ALS)

Change in Beck Depression Scale score (BDI)

Change in Difficulty in Emotion Regulation Scale Scores (DERS)

+3 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Cognitive Reappraisal-by-Distancing (CRD)Experimental Treatment1 Intervention

Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures usng practice pictures.

Group II: Control Downregulate Condition (CD)Active Control1 Intervention

Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.

0 / 1Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for Borderline Personality Disorder (BPD) like Dialectical Behavior Therapy (DBT) and Schema-focused therapy work by modifying dysfunctional thinking patterns and behaviors. DBT focuses on managing suicidal behaviors, improving emotional regulation, and enhancing interpersonal effectiveness. Schema-focused therapy aims to reshape deep-seated maladaptive beliefs formed in early life. Cognitive Reappraisal Training, similar to these therapies, helps patients reframe negative thoughts and emotions, which is crucial for reducing emotional dysregulation and improving overall functioning in BPD patients.