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Tryptophan Intake for Healthy Adults
N/A
Waitlist Available
Led By Glenda Courtney-Martin, PhD, RD
Research Sponsored by The Hospital for Sick Children
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Aged 18 to 45 years old (inclusive)
Fasting blood glucose, hemoglobin A1c (HbA1c), urea, creatinine and CRP levels within normal ranges for age.
Must not have
Unwilling to have blood drawn from a venous access or using a ventilated hood indirect calorimeter for the purposes of the study.
Taking medications known to affect protein/AA metabolism (e.g. steroids, anti-inflammatory medications, acetaminophen, selective serotonin reuptake inhibitors (SSRI))
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 hours
Awards & highlights
No Placebo-Only Group
Summary
This trial aims to develop a method to measure harmful compounds produced from the breakdown of tryptophan in adults, which can be used to help premature babies receiving total parenteral nutrition (TPN)
Who is the study for?
This trial is for healthy young adults. Specific eligibility criteria are not provided, but typically participants should have no significant health issues that could interfere with the study.
What is being tested?
The study aims to develop a method to measure compounds resulting from tryptophan breakdown. This will help understand its metabolism in stressed conditions like those experienced by premature babies on TPN.
What are the potential side effects?
Since this trial involves monitoring tryptophan intake in healthy individuals, side effects are expected to be minimal or related to potential dietary changes.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 45 years old.
Select...
My blood sugar and kidney function tests are within normal ranges.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I am willing to have blood drawn and participate in all required study procedures.
Select...
I am not taking steroids, anti-inflammatories, acetaminophen, or SSRIs.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 10 hours
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 hours
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Fractional Synthesis Rate (FSR) of tryptophan metabolites
Steady state
Secondary study objectives
Fractional synthesis rate (FSR)
Partitioning of tryptophan metabolism
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Experimental: Tryptophan in healthy young adults (18-45 years)Experimental Treatment1 Intervention
Tryptophan intake levels, up to 5 levels, will be tested in a random order in all subjects
Find a Location
Who is running the clinical trial?
The Hospital for Sick ChildrenLead Sponsor
712 Previous Clinical Trials
6,959,793 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,394 Previous Clinical Trials
26,527,852 Total Patients Enrolled
Glenda Courtney-Martin, PhD, RDPrincipal InvestigatorThe Hospital for Sick Children
5 Previous Clinical Trials
192 Total Patients Enrolled