Integrated Machine Learning Approach for High Cholesterol
(BEAT FH Trial)

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Pennsylvania

No Placebo Group

Trial Summary

What is the purpose of this trial?

The goal of this study is to identify individuals at high risk of FH, and to encourage the appropriate diagnosis and treatment of individuals at high risk of FH through the use of implementation science and behavioral economics principles. Phase 1: Applying the FIND FH tool to the health system EHR and gathering data for pilot development; Phase 2: Pilot development and implementation; Phase 3: Conduct a large-scale pragmatic trial consistent with recommendations and learnings from the pilots in Phase 2

Research Team

Eligibility Criteria

This trial is for patients at Penn Medicine who are identified by the FIND FH tool as likely having Familial Hypercholesterolemia (FH), but have not been clinically diagnosed with it. It's aimed at those who may be at high risk of this condition, which involves very high cholesterol levels.

Inclusion Criteria

You have been identified as having a high chance of having familial hypercholesterolemia (FH) by a special screening tool.

Must be a patient at Penn Medicine

Exclusion Criteria

Already have been clinically diagnosed with FH using the proper ICD-10 code

Treatment Details

Interventions

Testing centralized referral mechanisms for PCPs (Behavioural Intervention)
Testing out patient outreach methods (Behavioural Intervention)

Trial OverviewThe study tests new ways to find and manage FH using a machine learning tool within electronic health records. It includes refining referral processes for primary care providers and exploring patient outreach methods across three phases: data gathering, pilot development, and a large-scale pragmatic trial.

Participant Groups

2Treatment groups

Experimental Treatment

Group I: Patients without a primary care physician within the UPHS health systemExperimental Treatment1 Intervention

Patients without a primary care physician within the UPHS health system will receive direct outreach from the study team to invite them to schedule a visit with a lipid specialist for a formal evaluation of FH.

Group II: Patients with a primary care physician within the UPHS health systemExperimental Treatment2 Interventions

For patients with a primary care physician within the UPHS health system, their primary care physicians will be asked to review and sign physician referrals to a lipid specialist and invite patients to schedule a visit with a lipid specialist for a formal evaluation of FH.