← Back to Search

Trial of Hemodialysis Based Exercise for Strength Improvement Study (THESIS Trial)

N/A
Waitlist Available
Research Sponsored by St. Joseph's Healthcare Hamilton
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 and 20 weeks
Awards & highlights
No Placebo-Only Group

Summary

Study Hypothesis: The combination of aerobic and resistance exercise training will improve walking speed compared to either individual intervention. Brief Summary: Sixty hemodialysis participants who meet inclusion and exclusion criteria will be randomized to 20 weeks of supervised exercise, using either: (i) on-dialysis aerobic exercise using a bike ergometer; (ii) pre-dialysis leg strength training using weights; or (iii) both. The primary outcome is walking speed over 4-metres. Secondary outcomes will include: (i) short physical performance battery; (ii) health-related quality of life \[EuroQOL-5D-5L\]; (iii) Dialysis recovery time; (iv) Nottingham extended activities of daily living (EADL) index; (v) Leg strength; (vi) body composition and anthropometry.

Eligible Conditions
  • Kidney Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 and 20 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 and 20 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
change in walking speed over 20 weeks
Secondary study objectives
change in EuroQOL-5D-5L over 20 weeks
change in Nottingham extended activities of daily living index over 20 weeks
change in body anthropometry and composition over 20 weeks.
+3 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: aerobic exercise and resistance trainingExperimental Treatment2 Interventions
patients will undergo a combination of aerobic exercise and resistance training on an alternating schedule three time per week
Group II: aerobic exerciseActive Control1 Intervention
patients will undergo supervised exercise on a bike ergometer for 30 minutes three times per week during hemodialysis
Group III: resistance trainingActive Control1 Intervention
patients will undergo supervised lower extremity strength training three times per week pre-hemodialysis

Find a Location

Who is running the clinical trial?

St. Joseph's Healthcare HamiltonLead Sponsor
202 Previous Clinical Trials
26,865 Total Patients Enrolled
~5 spots leftby Jan 2026
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top