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Uric Acid Reducer
Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status (UA Trial)
N/A
Waitlist Available
Led By Samuel Klein, MD
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 hours after reducing uric acid
Awards & highlights
No Placebo-Only Group
Summary
The purpose of this study is to learn more about what is the effect of uric acid on oxidative stress and on the way the body metabolizes sugar in obese people. Understanding this may lead to better diseases such as diabetes.
Eligible Conditions
- Hyperuricemia
- Metabolic Syndrome
- High Uric Acid
- Obesity
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ before reducing uric acid
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before reducing uric acid
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Percent Increase in Insulin-stimulated Glucose Uptake
Secondary study objectives
AFTER Rasburicase Carbonylated Protein Ratio
AFTER Rasburicase Plasma FRAP (Fe⁺² · Lˉ¹)
AFTER Rasburicase Plasma TRAP
+4 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Obese subjects with high uric acidExperimental Treatment1 Intervention
Subjects with a body mass index = or \> 30 kg/m² with high uric acid (\>6 mg/dL)
Intervention: one single infusion of rasburicase (0.19 mg/kg FFM) infused over 30 min
Group II: Obese subjects with normal uric acidActive Control1 Intervention
Subjects with a body mass index = or \> 30 kg/m² with normal uric acid (= or \< 5 mg/dL)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Uric acid
Not yet FDA approved
Find a Location
Who is running the clinical trial?
Washington University School of MedicineLead Sponsor
2,000 Previous Clinical Trials
2,344,231 Total Patients Enrolled
Samuel Klein, MDPrincipal InvestigatorWashington University School of Medicine
28 Previous Clinical Trials
2,198 Total Patients Enrolled