tDCS for Parkinson's Disease

N/A

Waitlist Available

Led By Nathan C Rowland, MD,PhD

Research Sponsored by Medical University of South Carolina

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up subjects will undergo baseline ecog recording 5 min before tdcs starts, during tdcs (5 min after stimulation starts) and 5 min after tdcs stimulation ends. measurements will be made similarly during sham stimulation.

Summary

This trial will study the effects of transcranial direct current stimulation (tDCS) on subjects with movement deficits due to conditions like Parkinson's disease and stroke. The goal is to understand how tDCS works in order to improve this potentially useful therapy.

Who is the study for?

This trial is for adults over 18 who have previously agreed to be contacted about research studies at the Medical University of South Carolina. It's not suitable for pregnant individuals, those with scalp issues, a history of seizures, metal implants in the head/neck area, prior brain surgery or radiotherapy, or past intracranial tumors/infections/malformations.

What is being tested?

The study tests how transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, affects motor control in Parkinson's disease and stroke patients. Participants will undergo tDCS with both noninvasive and invasive recording methods to see if it improves movement symptoms.

What are the potential side effects?

Potential side effects from tDCS may include discomfort at the electrode site on the scalp, itching or tingling during stimulation, fatigue, headache or nausea post-treatment. In rare cases, there could be more serious risks like seizures.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ subjects will undergo baseline eeg recording 5 min before tdcs starts, during tdcs (5 min after stimulation starts) and 5 min after tdcs stimulation ends. measurements will be made similarly during sham stimulation.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~subjects will undergo baseline eeg recording 5 min before tdcs starts, during tdcs (5 min after stimulation starts) and 5 min after tdcs stimulation ends. measurements will be made similarly during sham stimulation.

This trial's timeline: 3 weeks for screening, Varies for treatment, and subjects will undergo baseline eeg recording 5 min before tdcs starts, during tdcs (5 min after stimulation starts) and 5 min after tdcs stimulation ends. measurements will be made similarly during sham stimulation. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in primary motor cortical (PriMC) beta oscillations during arm flexion in relation to anodal tDCS activation

Change in primary motor cortical (PriMC) beta oscillations during cued arm reaching in relation to anodal tDCS activation

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Stimulation (invasive recording)Experimental Treatment1 Intervention

Patients with Parkinson's disease undergoing surgery for deep brain stimulation will be studied using electrocorticography combined with transcranial direct current stimulation

Group II: Stimulation (noninvasive recording)Active Control1 Intervention

Patients with Parkinson's disease or chronic stroke will be assigned to undergo EEG recording and transcranial direct current stimulation.

Group III: Sham (noninvasive recording)Placebo Group1 Intervention

Patients with Parkinson's disease or chronic stroke will be assigned to undergo EEG recording and sham transcranial direct current stimulation.

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