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Nasal Iodine Swab vs Oral Antibiotic for Preventing Infections After Skin Cancer Surgery

N/A

Waitlist Available

Led By Nahid Y. Vidal, M.D.

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Able to swallow, retain, and absorb oral medications

Be older than 18 years old

Must not have

Patients with lesions on the legs, as dilute vinegar soaks are standard practice and this would be a confounder for preventing surgical site infection

Requiring oral antibiotic therapy for prophylaxis postoperative infectious endocarditis or hematogenous total joint infection

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 30 days after mms

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to compare the infection rates in patients who undergo Mohs micrographic surgery using two different approaches: one involves using a nasal swab with povidone iodine, and the other involves

Who is the study for?

This trial is for patients undergoing Mohs micrographic surgery, a procedure to remove skin cancer. Participants must meet certain health standards but specific inclusion and exclusion criteria are not detailed here.

What is being tested?

The study compares infection rates after skin cancer surgery between two groups: one treated with nasal iodine swabs and the other with standard oral antibiotics.

What are the potential side effects?

Possible side effects may include irritation or allergic reaction from the iodine swabs, and typical antibiotic-related issues like stomach upset or allergic reactions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can take pills and my body can absorb them.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have lesions on my legs and use vinegar soaks.

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I need oral antibiotics after surgery to prevent heart or joint infection.

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I am allergic to cefalexin, azithromycin, or clindamycin.

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I am currently on antibiotics or cannot use povidone-iodine due to an allergy or other reason.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 30 days after mms

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~30 days after mms

This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days after mms for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Effectiveness of nasal decolonization with povidone-iodine versus a standardized oral antibiotic prophylaxis protocol to prevent surgical site infection (SSI)

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Povidone Iodine nasal swabExperimental Treatment2 Interventions

Patients undergoing Mohs micrographic surgery (MMS) for malignant cutaneous neoplasms will receive nasal povidone-iodine swabs prior to skin reconstruction.

Group II: Oral antibiotic prophylaxis protocol (usual care)Experimental Treatment2 Interventions

Patients undergoing Mohs micrographic surgery (MMS) for malignant cutaneous neoplasms will receive standard of care, including the provision of an oral anti-staphylococcal antibiotic per the standardized Antibiotic Prophylaxis protocol currently used for clinical decision making in Dermatologic Surgery at Mayo Clinic Rochester.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Antibiotic

2008

Completed Phase 4

~6180

0 / 5Eligibility criteria met