What is the mechanism of action of this treatment?

The most common treatments for Terbinafine reactions, particularly when considering interactions with caffeine, involve managing cardiovascular symptoms such as changes in blood pressure or heart rate. Beta-blockers can be used to mitigate increased heart rate and hypertension by blocking the effects of adrenaline on the heart. Calcium channel blockers help relax and widen blood vessels, reducing blood pressure. These treatments are crucial for Terbinafine reaction patients because they help manage potentially dangerous cardiovascular side effects, ensuring patient safety and improving overall treatment outcomes.

What side effects are associated with this type of intervention?

Common side effects of terbinafine include gastrointestinal symptoms such as diarrhea, dyspepsia, and nausea, as well as dermatological reactions like rash and pruritus. Hepatotoxicity is a serious but less common side effect. Cardiovascular side effects are not typically associated with terbinafine alone, but the interaction with caffeine may potentially affect blood pressure and heart rate, as suggested by the study on their combined use.

What prior FDA approvals exist?

There are no specific FDA-approved treatments mentioned for reactions to terbinafine, particularly those involving cardiovascular parameters. The context provided discusses a study hypothesizing that caffeine consumption might affect cardiovascular parameters in patients taking terbinafine, but it does not detail any approved treatments. Generally, managing adverse reactions to terbinafine would involve discontinuing the drug and addressing symptoms, potentially with supportive care or alternative medications as advised by a healthcare provider.

What other types of research exist?

For patients experiencing cardiovascular interactions between caffeine and terbinafine, promising alternatives include: 1. Avoiding caffeine and using non-stimulant beverages like herbal teas. 2. Using alternative antifungal medications such as itraconazole or fluconazole, which have different interaction profiles. Consultation with a healthcare provider is essential to tailor the treatment plan.

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Caffeine Consumption for Terbinafine Reaction

N/A

Waitlist Available

Led By Shari Lipner, MD, PhD

Research Sponsored by Weill Medical College of Cornell University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 30 min after consuming caffeine, 60 minutes after consuming caffeine

Summary

This trial studies if drinking caffeine while taking terbinafine for nail fungus affects heart rate or blood pressure. Terbinafine can make caffeine stay in the body longer, possibly causing these changes.

Who is the study for?

This trial is for adults over 18 with a nail infection called onychomycosis who are about to begin treatment with terbinafine. It's not open to pregnant or breastfeeding individuals, those unable to consent, or anyone with a history of anxiety or high blood pressure.

What is being tested?

The study aims to see if drinking caffeinated coffee affects heart rate and blood pressure differently than decaffeinated coffee in patients taking the antifungal medication terbinafine.

What are the potential side effects?

Potential side effects may include changes in heart rate and blood pressure due to caffeine consumption while on terbinafine. Other common side effects from caffeine like jitteriness, insomnia, or digestive issues might also be observed.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 30 min after consuming caffeine, 60 minutes after consuming caffeine

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 30 min after consuming caffeine, 60 minutes after consuming caffeine

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 30 min after consuming caffeine, 60 minutes after consuming caffeine for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Blood Pressure

Change in Heart Rate

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Caffeinated GroupActive Control1 Intervention

Caffeinated coffee, 1 cup, 8 oz water setting, 95 mg caffeine

Group II: Decaffeinated GroupPlacebo Group1 Intervention

Decaffeinated coffee, 1 cup, 8 oz water setting

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Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

The most common treatments for Terbinafine reactions, particularly when considering interactions with caffeine, involve managing cardiovascular symptoms such as changes in blood pressure or heart rate. Beta-blockers can be used to mitigate increased heart rate and hypertension by blocking the effects of adrenaline on the heart. Calcium channel blockers help relax and widen blood vessels, reducing blood pressure. These treatments are crucial for Terbinafine reaction patients because they help manage potentially dangerous cardiovascular side effects, ensuring patient safety and improving overall treatment outcomes.

Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats.Quantitative design of optimal analgesic combination of acetaminophen, caffeine, and butalbital.Grapefruit juice-terfenadine single-dose interaction: magnitude, mechanism, and relevance.