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Study in Adult and Pediatric Patients With HSCT-TMA

N/A
Waitlist Available
Research Sponsored by Alexion Pharmaceuticals, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 26 weeks and 52 weeks after hsct-tma diagnosis
Awards & highlights
No Placebo-Only Group

Summary

This is an observational, retrospective study designed to assess outcomes in patients diagnosed with hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA) who were not treated with complement component (C5) inhibitor therapy. Data required to evaluate study outcomes will be abstracted from the medical records of all patients who meet study eligibility criteria.

Eligible Conditions
  • Thrombotic Microangiopathy
  • Stem Cell Transplant Complications

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from baseline to 26 weeks and to 52 weeks after hsct-tma diagnosis
This trial's timeline: 3 weeks for screening, Varies for treatment, and from baseline to 26 weeks and to 52 weeks after hsct-tma diagnosis for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Proportion of patients achieving TMA Response
Secondary study objectives
Changes in individual components of TMA response
Nonrelapse mortality

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients Diagnosed with HSCT-TMAExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

Alexion Pharmaceuticals, Inc.Lead Sponsor
263 Previous Clinical Trials
140,591 Total Patients Enrolled
Alexion PharmaceuticalsLead Sponsor
230 Previous Clinical Trials
36,604 Total Patients Enrolled
AlexionLead Sponsor
246 Previous Clinical Trials
38,518 Total Patients Enrolled
~0 spots leftby Dec 2025
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