Astelin

Blepharitis allergic, Rhinitis, Vasomotor, Hay Fever + 6 more

Treatment

1 Active Study for Astelin

What is Astelin

Azelastine

The Generic name of this drug

Treatment Summary

Azelastine is a medication used to treat allergies and nasal congestion. It comes in the form of an intranasal spray and an ophthalmic solution. Azelastine was approved by the FDA in 1996 and is sometimes combined with fluticasone propionate as a nasal spray called Dymista, which is used to treat seasonal allergies in people 6 years and older.

Astelin

is the brand name

image of different drug pills on a surface

Astelin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Astelin

Azelastine

1996

56

Effectiveness

How Astelin Affects Patients

Azelastine works by blocking the effects of histamine, which helps relieve allergy symptoms. The effects of this drug can be felt as quickly as 15 minutes after taking intranasal formulations or 3 minutes after taking ophthalmic solutions. Taking intranasal formulations produces peak effects 4-6 hours after the initial dose, and these effects are maintained for 12 hours.

How Astelin works in the body

Azelastine is a medication used to relieve the symptoms of allergies. It works by blocking histamine H1-receptors, which are located on nerve endings, smooth muscle cells, and glandular cells. When allergens enter the body, they trigger mast cells to release histamine. This histamine binds to the H1-receptors and causes typical allergic symptoms like itching and sneezing. Azelastine also works by stabilizing mast cells and preventing them from releasing other substances like interleukin-6 and leukotrienes that can cause further allergic reactions. It also reduces the amount of

When to interrupt dosage

The prescribed measure of Astelin is contingent upon the identified condition, including Hay Fever, Disorder of eye and Keratoconjunctivitis. The dose of the medication is contingent upon the delivery procedure (e.g. Nasal or Solution / drops) featured in the table beneath.

Condition

Dosage

Administration

Keratoconjunctivitis

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic

Administration, Intranasal

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic

allergic eye disorders

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic

Rhinitis, Vasomotor

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic

Blepharitis allergic

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic

Rhinitis, Allergic

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic

Allergy to Tree Pollen

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic

Hay Fever

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic

Allergic Conjunctivitis (AC)

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic

Warnings

There are 20 known major drug interactions with Astelin.

Common Astelin Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Azelastine.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Azelastine.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Azelastine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Azelastine.

Copanlisib

Major

The metabolism of Copanlisib can be decreased when combined with Azelastine.

Astelin Toxicity & Overdose Risk

Overdosing on azelastine can cause drowsiness and should be kept away from children, as it can lead to serious adverse effects. The lowest dose of azelastine that was toxic to rats was 580mg/kg. If overdose occurs, general supportive care should be provided.

image of a doctor in a lab doing drug, clinical research

Astelin Novel Uses: Which Conditions Have a Clinical Trial Featuring Astelin?

There are 9 ongoing clinical trials examining the potential of Intranasal Administration of Astelin in treating Disorders of the Eye and Allergic Blepharitis.

Condition

Clinical Trials

Trial Phases

Rhinitis, Vasomotor

1 Actively Recruiting

Not Applicable

Administration, Intranasal

0 Actively Recruiting

Keratoconjunctivitis

0 Actively Recruiting

Hay Fever

0 Actively Recruiting

Allergy to Tree Pollen

0 Actively Recruiting

Allergic Conjunctivitis (AC)

0 Actively Recruiting

Rhinitis, Allergic

0 Actively Recruiting

allergic eye disorders

0 Actively Recruiting

Blepharitis allergic

0 Actively Recruiting

Astelin Reviews: What are patients saying about Astelin?

5

Patient Review

3/27/2013

Astelin for Inflammation of the Nose due to an Allergy

I've tried a lot of different treatments over the years, and this is still the best one that gives me relief. I mostly use it at night because it makes me drowsy, but if I drink coffee in the morning I can stave off the sleepiness long enough to get through my day.

5

Patient Review

1/21/2012

Astelin for Inflammation of the Nose due to an Allergy

This stuff is awesome.

5

Patient Review

4/18/2012

Astelin for Vasomotor Rhinitis

After a bad case of fluid buildup, I lost over 50 lbs but my sinuses went out of control. This has been the best medication I've tried yet for my sinus problems.

4.7

Patient Review

9/4/2015

Astelin for Inflammation of the Nose due to an Allergy

I am using this medication in conjunction with Flonase and am seeing good results.

4

Patient Review

3/26/2017

Astelin for Non-Seasonal Allergic Runny Nose

This is the most effective nasal spray I've tried, and it doesn't have any of the negative long-term effects that other treatments do.

4

Patient Review

2/12/2018

Astelin for Inflammation of the Nose due to an Allergy

I started using this six days ago to help with my congestion and headaches. It does make me sleepy, so I'm now using it at night. Flonase wasn't helping much anymore.

2.3

Patient Review

9/3/2012

Astelin for Inflammation of the Nose due to an Allergy

I was given this medication by my doctor after getting a Kenalog shot. It's very expensive and, in my opinion, does not help at all. Eyes itchy and watery, sneezing, etc. I'm counting down the days until I can get another shot!

2.3

Patient Review

10/30/2013

Astelin for Seasonal Runny Nose

I was on Astepro, but my new insurance coverage wouldn't allow for that. So, I was switched to this treatment instead. Unfortunately, I wake up multiple times a night now due to post nasal drip and the consequent coughing and choking sensation.

2.3

Patient Review

8/27/2012

Astelin for Inflammation of the Nose due to an Allergy

So far, this hasn't helped me as much as I'd hoped.

2

Patient Review

4/24/2020

Astelin for Seasonal Runny Nose

I only took this medication for two days because the side effects were too much for me to handle. I had trouble sleeping, felt nauseous, and developed a pins-and-needles sensation in my extremities. Additionally, an hour after using the spray my nose was totally plugged up.

1

Patient Review

11/1/2018

Astelin for Non-Seasonal Allergic Runny Nose

I had some really unpleasant side effects after taking this medication. I felt incredibly tired, my body hurt, and I could barely keep my eyes open. Thankfully, these problems went away eventually. However, I definitely will not be taking this again.

1

Patient Review

8/25/2016

Astelin for Inflammation of the Nose due to an Allergy

The taste this medication leaves is absolutely vile, and it lingers for hours. I would not recommend it to anyone.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about astelin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Astelin used for?

"This medication reduces nasal symptoms such as runny/itching/stuffy nose, sneezing, and post-nasal drip caused by allergies or other conditions. Azelastine is an antihistamine."

Answered by AI

Is azelastine the same as Flonase?

"No, azelastine (nasal) is not the same as Flonase. Azelastine (nasal) is an antihistamine medication while Flonase contains a steroid (fluticasone)."

Answered by AI

Is Astelin nasal spray a steroid?

"Azelastine nasal spray is a non-steroidal treatment and has some advantages over intranasal corticosteroids in the treatment of SAR even though its anti-inflammatory effect is not as strong."

Answered by AI

Is Astelin nasal spray safe?

"Azalestime Hydrochloride is an effective and safe antihistamine that can be administered nasally to treat perennial and seasonal allergic rhinitis."

Answered by AI

Clinical Trials for Astelin

Image of Cedars-Sinai Medical Center Otolaryngology Clinics in Los Angeles, United States.

Lavender Aromatherapy for Anxiety and Pain During Otolaryngologic Procedures

18+
All Sexes
Los Angeles, CA

The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting. The main questions it aims to answer are: * Does lavender aromatherapy help reduce anxiety and/or pain, and improve patient comfort during awake otolaryngologic procedures in the clinic? * Do patients subjectively find aromatherapy relaxing and/or beneficial during the procedure? Researchers will compare lavender aromatherapy to placebo (an odorless liquid) to see if lavender aromatherapy helps improve patient comfort during their awake procedure Participants will: * Have their scheduled procedure performed with lavender aromatherapy or placebo during the duration of the procedure * Take a short, less than 1 minute questionnaire both before and after the procedure, describing their levels of anxiety, pain and subjective impressions of the aromatherapy

Recruiting
Paid Trial

Cedars-Sinai Medical Center Otolaryngology Clinics

Ankona Ghosh, MD