Mephyton

Jaundice, Obstructive, long-acting anticoagulant rodenticides, Vitamin K Deficiency + 17 more

Treatment

10 FDA approvals

19 Active Studies for Mephyton

What is Mephyton

Phylloquinone

The Generic name of this drug

Treatment Summary

Vitamin K1 (also known as phylloquinone or phytonadione) is a fat-soluble vitamin that helps the body form clotting factors II, VII, IX, and X. It is used to treat clotting disorders caused by a lack of vitamin K. This vitamin has been available since 1939 and was approved by the FDA before 1955.

Mephyton

is the brand name

image of different drug pills on a surface

Mephyton Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Mephyton

Phylloquinone

1955

65

Approved as Treatment by the FDA

Phylloquinone, also known as Mephyton, is approved by the FDA for 10 uses including Jaundice, Obstructive and Hypoprothrombinemia .

Jaundice, Obstructive

Used to treat Jaundice, Obstructive in combination with Taurocholic acid

Hypoprothrombinemia

Fistula, Biliary

Used to treat Fistula, Biliary in combination with Taurocholic acid

antibacterial therapy

Biliary Fistula

Used to treat Fistula, Biliary in combination with Taurocholic acid

hemorrhagic disease of the newborn

Hypoprothrombinemias

Jaundice, Obstructive

Used to treat Jaundice, Obstructive in combination with Taurocholic acid

Hemorrhagic Disease of Newborn

Salicylate

Effectiveness

How Mephyton Affects Patients

Phylloquinone is a vitamin K used to treat problems with blood clotting due to a lack of or reduced activity of vitamin K. It stays in the body for a long time and is safe to take in large doses. People taking this medication should have their prothrombin time monitored, and healthcare professionals should be aware of the risk of allergic reactions with injections.

How Mephyton works in the body

Vitamin K helps the body form blood clots by helping clotting proteins bind to calcium ions. This allows them to become active and be released into the blood, which helps stop bleeding. Vitamin K might also help prevent joint calcification, increased bone density, and reducing the risk of vascular calcification. These benefits are still being studied.

When to interrupt dosage

The suggested portion of Mephyton is contingent upon the diagnosed condition, like Sprue, Vitamin supplementation and Ulcerative Colitis. The measure of dosage is contingent upon the method of delivery outlined in the table beneath.

Condition

Dosage

Administration

Biliary Fistula

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Ulcerative Colitis

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Vitamin supplementation

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

long-acting anticoagulant rodenticides

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Anticoagulant Therapy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Vitamin supplementation therapy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

hemorrhagic disease of the newborn

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

vitamin K

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Crohn Disease

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Blood Coagulation Disorders

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Celiac Disease

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Jaundice, Obstructive

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Vitamin K Deficiency

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Hypoprothrombinemias

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Intestinal resection

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Hemorrhagic Disease of Newborn

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Salicylate

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Cystic Fibrosis

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Celiac Disease

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

antibacterial therapy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Injection, solution, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Emulsion, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Intravenous, Solution - Parenteral, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Injection, powder, lyophilized, for solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Capsule - Oral, Capsule, Injection - Intravenous, Injection, Solution, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Intramuscular, Solution / drops - Oral, Emulsion - Intramuscular; Intravenous; Subcutaneous

Warnings

Mephyton has one contraindication, so it must not be utilized when encountering the conditions in the following table.

Mephyton Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Phylloquinone may interact with Pulse Frequency

There are 20 known major drug interactions with Mephyton.

Common Mephyton Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The therapeutic efficacy of (R)-warfarin can be decreased when used in combination with Phylloquinone.

(S)-Warfarin

Major

The therapeutic efficacy of (S)-Warfarin can be decreased when used in combination with Phylloquinone.

4-hydroxycoumarin

Major

The therapeutic efficacy of 4-hydroxycoumarin can be decreased when used in combination with Phylloquinone.

Acenocoumarol

Major

The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Phylloquinone.

Clorindione

Major

The therapeutic efficacy of Clorindione can be decreased when used in combination with Phylloquinone.

Mephyton Toxicity & Overdose Risk

Taking too much Vitamin K1 can be dangerous and can cause adverse reactions, particularly when administered intravenously. The toxic dose of Vitamin K1 in mice is 1170 mg/kg when administered intravenously, and more than 24180 mg/kg when taken orally. If someone has overdosed on Vitamin K1, they should receive appropriate care and treatment.

Mephyton Novel Uses: Which Conditions Have a Clinical Trial Featuring Mephyton?

100 active trials are currently in progress to assess the potential of Mephyton in alleviating Crohn Disease, Hemorrhagic Disease of the Newborn, and Obstructive Jaundice.

Condition

Clinical Trials

Trial Phases

Ulcerative Colitis

17 Actively Recruiting

Phase 3, Phase 2, Phase 1, Not Applicable, Phase 4

Jaundice, Obstructive

0 Actively Recruiting

Blood Coagulation Disorders

0 Actively Recruiting

Cystic Fibrosis

0 Actively Recruiting

Vitamin K Deficiency

0 Actively Recruiting

Vitamin supplementation

0 Actively Recruiting

Crohn Disease

0 Actively Recruiting

antibacterial therapy

0 Actively Recruiting

Hemorrhagic Disease of Newborn

0 Actively Recruiting

Celiac Disease

0 Actively Recruiting

Hypoprothrombinemias

0 Actively Recruiting

vitamin K

0 Actively Recruiting

hemorrhagic disease of the newborn

0 Actively Recruiting

Vitamin supplementation therapy

0 Actively Recruiting

long-acting anticoagulant rodenticides

0 Actively Recruiting

Celiac Disease

0 Actively Recruiting

Salicylate

0 Actively Recruiting

Anticoagulant Therapy

2 Actively Recruiting

Phase 4, Not Applicable

Intestinal resection

0 Actively Recruiting

Biliary Fistula

0 Actively Recruiting

Mephyton Reviews: What are patients saying about Mephyton?

3.3

Patient Review

2/5/2009

Mephyton for Decreased Blood-Clotting from Low Vitamin K

This treatment helped me a lot, but I still experienced some side effects.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about mephyton

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of vitamin K injection?

"The following effects may occur at the injection site: pain, swelling, or soreness. You may also experience temporary flushing, taste changes, dizziness, rapid heartbeat, sweating, shortness of breath, or bluish lips/skin/nails. If any of these effects persist or worsen, tell your doctor or pharmacist promptly."

Answered by AI

Is phytonadione the generic name?

"Mephyton is a prescription drug used to treat various medical conditions. These include nutritional deficiencies, a low level of blood clotting factors, and reversing the effects of Warfarin. Mephyton may be used alone or in conjunction with other medications. It belongs to a class of drugs known as Hemostatics, which are vitamins that help promote blood clotting."

Answered by AI

What is Mephyton used for?

"Mephyton is used to prevent bleeding when blood clotting is impaired due to low levels of vitamin K or reduced activity of vitamin K."

Answered by AI

What is the generic name of vitamin K?

"Phytonadione is used to prevent bleeding in people who have blood clotting problems or too little vitamin K in their bodies. Phytonadione is a type of vitamin medication."

Answered by AI

Clinical Trials for Mephyton

Image of McMaster Children's Hospital - Digestive Diseases Clinic in Hamilton, Canada.

Vancomycin for Ulcerative Colitis

18+
All Sexes
Hamilton, Canada

This clinical trial tests if oral vancomycin can safely treat active ulcerative colitis (UC) in adults who also have primary sclerosing cholangitis (PSC), a liver condition. The main questions it aims to answer are: * Can oral vancomycin improve UC symptoms as measured by Mayo score at 4 weeks? * Is oral vancomycin safe and tolerable in this patient group? Participants will be compared to see if vancomycin works better than placebo. Participants will: * Take oral vancomycin (250 mg twice daily) or identical placebo capsules for 4 weeks * Have the option for 4 more weeks of open-label vancomycin after the blinded phase * Attend clinic visits at baseline, week 4, and follow-up for Mayo scoring, endoscopy, blood/stool tests, and safety checks * Track treatment adherence and side effects The study primarily assesses if the trial can recruit 14 participants, retain them, achieve good adherence, and follow protocol procedures (feasibility). Secondary goals include safety (adverse events) and early signs of benefit in UC activity, liver tests, and gut bacteria balance. This pilot will guide larger future studies.

Phase 2
Waitlist Available

McMaster Children's Hospital - Digestive Diseases Clinic

Neeraj Narula, MD

Image of MUHC - Montreal General Hospital in Montreal, Canada.

Ustekinumab for Crohn's Disease and Ulcerative Colitis

18+
All Sexes
Montreal, Canada

The goal of this clinical trial is to evaluate whether disease remission can be maintained when biologic therapy is reduced in patients with Crohn"s disease (CD) and ulcerative colitis (UC) taking ustekinumab (UST). The main question it aims to answer is: Can we de-escalate UST subcutaneous dose either from every 4 weeks (Q4) to every 8 weeks (Q8) or every 8 weeks (Q8) to every 12 weeks (Q12) in CD or UC patients in deep remission without loosing their response? Researchers will follow UST blood levels, inflammation markers and intestinal mucosa integrity and to see if UST dose can be reduced while maintaining clinical remission. Participants will: Change UST dosing from Q4 to Q8 or from Q8 to Q12. Visit the clinic once every 12 weeks for checkups and tests.

Phase 4
Recruiting

MUHC - Montreal General Hospital

Janssen Inc.

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Image of Rubix LS in Lawrence, United States.

Mirikizumab for Inflammatory Bowel Disease

60 - 99
All Sexes
Lawrence, MA

This research study looks at how safe and effective a medicine called Mirikizumab is for treating older adults (aged 60 and above) who have moderate to severe Crohn's disease (CD) or ulcerative colitis (UC). These two conditions, known as inflammatory bowel diseases (IBD), cause inflammation (swelling and irritation) in the digestive tract. Older adults with these conditions often have other health issues and face increased risks and complications, making it challenging for them to use certain treatments. Mirikizumab is already approved by the FDA for adults with IBD, but there's limited information about how well it works specifically for older adults. This study aims to fill that gap by seeing if Mirikizumab can help these patients safely manage their condition. The study plans to enroll around 150 people from various locations across the United States. Everyone participating will receive Mirikizumab according to the standard, FDA-approved guidelines. The main goal is to see how many participants achieve clinical remission, meaning their symptoms significantly improve or disappear, after 24 weeks of treatment. Researchers will also look at whether this remission lasts up to 48 weeks, how well symptoms are controlled without steroids, how treatment affects indicators of inflammation (such as blood tests), and how the participants feel overall based on their own reports. The safety of Mirikizumab will also be closely monitored throughout the study by regularly checking for any side effects. This study hopes to provide clearer information to help older adults with IBD and their doctors make better treatment decisions, ultimately improving health outcomes and quality of life.

Phase 4
Waitlist Available

Rubix LS

Eli Lilly and Company

Image of Toronto Immune and Digestive Health Institute in North York, Canada.

Healing Circuits™ for Inflammatory Bowel Disease

18 - 75
All Sexes
North York, Canada

The purpose of this study is to test the impact of Healing Circuits™; a structured mental health support model on IBD patients. The eligible study participants will be randomly divided into two groups: 1. the group receiving structured mental health support with a social worker and 2. the group receiving structured mental health support via a self-directed online curriculum. Both groups will be receiving the same type of therapy, Healing Circuits™, but the group receiving the therapy via the online self-directed curriculum will be receiving the therapy mostly by web-based video instruction. The two groups will be evaluated over a period of 12 months.

Recruiting
Has No Placebo

Toronto Immune and Digestive Health Institute

Mark Silverberg, MD, PhD

Amgen

Image of Carolina Digestive Diseases- Site Number : 8400013 in Greenville, United States.

SAR441566 for Ulcerative Colitis

18 - 75
All Sexes
Greenville, NC

This is a Phase 2, multinational, multicenter, randomized, double-blind, placebo-controlled, dose ranging study to evaluate the efficacy and safety of SAR441566 in adults with moderate-to-severe UC. The primary objective of this study is to assess efficacy of different doses of SAR441566 on clinical remission in participants with moderate-to-severe ulcerative colitis. This study will include a screening period of up to 28 days (+ 7 calendar days if needed) followed by the main study treatment period of 52 weeks which will be comprised of a double blind (DB) treatment period with 12 weeks of induction period followed by a maintenance period of 40 weeks and 2-week follow-up after end of treatment. Additionally, an Open Label (OL) period of up to 40 weeks will be offered to eligible participants. * The study duration will be up to 59 weeks. * The treatment duration will be up to 52 weeks in the DB arm and up to 40 weeks in the OL arm. * The number of visits will be 12 for the main study treatment period and 8 for the OL treatment period.

Phase 2
Recruiting

Carolina Digestive Diseases- Site Number : 8400013 (+28 Sites)

Sanofi

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Image of University of Chicago in Chicago, United States.

Therapy De-escalation for Ulcerative Colitis

18 - 75
All Sexes
Chicago, IL

The goal of this study is to better understand treatment strategies for people with ulcerative colitis (UC). Researchers will compare patients with UC in histologic remission (no evidence of inflammation or active disease on endoscopy and biopsies) who continue to take medical therapy to patients with UC who de-escalate (decrease or discontinue) medical therapy. Both treatment strategies are considered within regular medical practice. Researchers want to find out whether remission can be maintained after de-escalation of therapy. Participants will be: * either be randomly assigned to continue medical therapy or de-escalate medical therapy -OR- be assigned per the participant's preference * clinically managed according to regular medical care * asked to provide blood, stool (poop), and tissue samples for study purposes

Recruiting
Has No Placebo

University of Chicago

David T Rubin, MD

Image of University of Colorado. School of Medicine in Denver, United States.

Decision-Making Tool for Blood Thinners

18+
All Sexes
Denver, CO

The purpose of this project is to implement and evaluate a shared-decision making (SDM) tool called DDInteract that was developed to support decision making for drug-drugs interactions while on oral anticoagulants. DDInteract will be implemented in clinics at the University of Utah, University of Colorado and University of Vanderbilt. DDInteract will be launched from within the electronic health record (EHR) retrieving patient-specific risk factors, will calculate the risk of harm, and will allow providers and patients to dynamically explore "what if" scenarios to optimize treatment and minimize risk. DDInteract will enable shared-decision making using individually-tailored information on the potential benefits and harms of drug interactions in anticoagulated patients.

Recruiting
Has No Placebo

University of Colorado. School of Medicine (+2 Sites)

Daniel C Malone, PhD

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We made a collection of clinical trials featuring Mephyton, we think they might fit your search criteria.
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