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What is Metoprolol Tartrate
MetoprololThe Generic name of this drug
Treatment SummaryMetoprolol is a medication used to block the effects of certain hormones in the body. It is available in both an immediate-release and extended-release form and can be used to treat high blood pressure, heart failure, and angina. Metoprolol was developed in 1969 and approved by the FDA in 1978. It is widely prescribed around the world and is one of the preferred treatments for heart-related conditions.
Lopressoris the brand name
Metoprolol Tartrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lopressor
Metoprolol
1978
983
Approved as Treatment by the FDA
Metoprolol, also known as Lopressor, is approved by the FDA for 4 uses including Hypertension and Hypertensive disease .Hypertension
Used to treat nonresponsive to antihypertensive monotherapy in combination with Hydrochlorothiazide
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide
Hemodynamically Stable
Heart Attack
Effectiveness
How Metoprolol Tartrate Affects PatientsWhen used correctly, metoprolol can help slow down the heart rate and reduce the amount of oxygen the heart needs to function. It has also been used to treat arrhythmia and has been found to reduce sudden cardiac death and heart attack in individuals who have had a heart attack. In clinical trials performed in 1990, taking metoprolol long-term after a heart attack reduced mortality and re-infarction by 17%.
How Metoprolol Tartrate works in the bodyMetoprolol is a medication that works to decrease the activity of certain receptors in the heart, resulting in a reduced heart rate and lower blood pressure. It does not affect other parts of the body, such as the nervous system or muscle cells.
When to interrupt dosage
The dose of Metoprolol Tartrate is contingent upon the determined illness, such as Hemodynamically Stable, Thyroid Crisis and Atrial Fibrillation. The volume of dosage shifts as per the method of delivery (e.g. Tablet, coated or Tablet - Oral) featured in the table beneath.Condition
Dosage
Administration
Chest Pain
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Heart Attack
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Migraine Disorders
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Atrial Fibrillation
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Thyroid Crisis
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Migraine
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hemodynamically Stable
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Tachycardia, Supraventricular
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Metoprolol Tartrate has seven restrictions. If you suffer from any of the circumstances listed in the table below, Metoprolol Tartrate should not be administered.Metoprolol Tartrate ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Metoprolol may interact with Pulse Frequency
Heart Block
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Heart Decompensation
Do Not Combine
Pulse Frequency
Do Not Combine
severe bradycardia
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Common Metoprolol Tartrate Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Metoprolol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Metoprolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Metoprolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Metoprolol.
Agrostis stolonifera pollen
Major
The risk of a hypersensitivity reaction to Agrostis stolonifera pollen is increased when it is combined with Metoprolol.
Metoprolol Tartrate Toxicity & Overdose RiskThe toxic dose of metoprolol in rats is 3090-4670mg/kg. Signs of an overdose on this drug include slow heart rate, low blood pressure, difficulty breathing, and heart failure. If someone takes too much metoprolol, it is recommended to induce vomiting followed by treatment for the symptoms. Metoprolol is not known to cause cancer, mutations, or fertility problems. Long-term use at high doses may result in small benign lung tumors.
Metoprolol Tartrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Metoprolol Tartrate?
At present, there are 319 ongoing investigations assessing the possible benefits of Metoprolol Tartrate for Hypesthesia, Thyroid Crisis and Hypertensive Disease.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
90 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Chest Pain
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Heart Attack
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3
Thyroid Crisis
0 Actively Recruiting
Hypesthesia
11 Actively Recruiting
Not Applicable, Phase 1
Hemodynamically Stable
0 Actively Recruiting
Tachycardia, Supraventricular
1 Actively Recruiting
Not Applicable
Migraine
50 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Hypesthesia
4 Actively Recruiting
Not Applicable
Hypertension
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Migraine Disorders
1 Actively Recruiting
Phase 3
Metoprolol Tartrate Reviews: What are patients saying about Metoprolol Tartrate?
5Patient Review
1/31/2022 This medication has been a literal lifesaver. For years it's kept my heart rhythm in check and prevented me from going into A-Fib.
5Patient Review
12/9/2021 I've been taking this medication for seven years now to help with an irregular heartbeat. When I first started the medication, I experienced some side effects like a fast heartbeat, chest pain, dizziness, drowsiness, and weird dreams. However, overall this medication has helped me a lot by lowering my heart rate and reducing chest pains.
4.7Patient Review
2/12/2020 This medication has been great for managing my blood pressure. I'm really pleased with the results.
3.7Patient Review
6/6/2020 I bruise and sometimes even bleed when I lightly bump my arms; it's really quite a problem.
3Patient Review
1/17/2022 I gained 75 pounds while taking this medication and also experienced bad allergic reactions, whelping, swelling, itching, hair loss, and diarrhea. I can't breathe well because of the weight gain, so I'll be asking my doctor to take me off the medication this week.
Patient Q&A Section about metoprolol tartrate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are side effects of metoprolol tartrate?
"Side effects may include: feeling dizzy or tired; depression; confusion; memory problems; nightmares; difficulty sleeping; diarrhea; or a mild itch or rash."
Answered by AI
What is the difference between metoprolol and metoprolol tartrate?
"The main difference between metoprolol tartrate and metoprolol succinate is that metoprolol tartrate is only available as an immediate-release tablet which means it must be taken several times per day, whereas metoprolol succinate is an extended-release tablet that can be taken once a day."
Answered by AI
What is metoprolol tartrate given for?
"Metoprolol is used in combination with other medications to treat high blood pressure, which can prevent strokes, heart attacks, and kidney problems. This medication is also effective in treating chest pain and improving survival rates after a heart attack."
Answered by AI
What is the best time of day to take metoprolol tartrate?
"This medication should be taken with a meal or just after a meal. The medicine should be taken at the same time each day. The capsule should be swallowed whole and not crushed, chewed, broken, or opened. A Toprol XL tablet can be divided in half if your doctor has told you to do so."
Answered by AI