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What is Orapred
Prednisolone phosphateThe Generic name of this drug
Treatment SummaryPrednisolone phosphate is a steroid medication used to reduce inflammation and suppress the immune system. It is also used to treat certain types of tumors. The drug was approved by the FDA in 1973 and can produce effects such as constricting blood vessels.
Pediapredis the brand name
Orapred Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pediapred
Prednisolone phosphate
1986
71
Approved as Treatment by the FDA
Prednisolone phosphate, also called Pediapred, is approved by the FDA for 24 uses such as Conjunctivitis and Uveitis .Conjunctivitis
Uveitis
Endocrine System Diseases
Swollen feet or ankles
Giant Cell Arteritis
Skin Diseases
Hypersensitivity
Multiple Sclerosis
Gastroenteritis
Collagen Diseases
Neoplastic Disease
Uveitis
Respiratory Diseases
Multiple sclerosis exacerbation
Dermatological Disease
Endocrine Disorders
Allergic Conditions
Uveitis
Ophthalmia, Sympathetic
Edema
Disease
Temporal Arteritis
Gastrointestinal Diseases
Ocular Inflammation
Effectiveness
How Orapred Affects PatientsPrednisolone works by blocking certain signals in the body that can lead to inflammation. It is only active in the body for a short time (2-4 hours), but the amount prescribed can be much higher than what the body makes naturally. People taking prednisolone should be aware of the risk of suppressing the body's hormone system and becoming more vulnerable to infections.
How Orapred works in the bodyCorticosteroids work to reduce inflammation in the body. They do this by affecting the flow of blood vessels and blocking white blood cells from travelling to sites of inflammation. Corticosteroids also change how certain genes are expressed, causing anti-inflammatory effects. Low doses reduce inflammation while high doses weaken the immune system. If taken for a long time, corticosteroids can cause an increase in sodium and decrease in potassium levels.
When to interrupt dosage
The proposed dosage of Orapred is contingent upon the indicated affliction, including Uveitis, Ocular Inflammation and Ophthalmia, Sympathetic. The measure of dosage is set by the method of administration specified in the table below.Condition
Dosage
Administration
Multiple Sclerosis
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Swollen feet or ankles
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Skin Diseases
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Collagen Diseases
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Respiratory Diseases
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Disease
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Endocrine System Diseases
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Uveitis
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Urinary Tract Infection (UTI)
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Conjunctivitis
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Giant Cell Arteritis
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Gastroenteritis
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Hypersensitivity
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Ophthalmia, Sympathetic
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Neoplastic Disease
15.0 mg/mL, , 25.0 mg/mL, 10.0 mg, 15.0 mg, 30.0 mg, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 20.0 mg/mL, 1.0 %, 0.125 %, 0.5 %, 2.3 mg/mL, 1.25 mg/mL
, Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Liquid; Solution / drops, Liquid; Solution / drops - Ophthalmic, Liquid - Oral
Warnings
Orapred has one contraindication and should not be consummated together with the conditions given in the following table.Orapred ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Prednisolone Phosphate may interact with Pulse Frequency
Common Orapred Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Prednisolone phosphate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Prednisolone phosphate.
Aldesleukin
Major
The therapeutic efficacy of Aldesleukin can be decreased when used in combination with Prednisolone phosphate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Prednisolone phosphate.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Prednisolone phosphate.
Orapred Toxicity & Overdose RiskNot much is known about acute Glucocorticoid overdose. Chronic overdose, however, can cause mental symptoms, a round face, fat deposits, and water retention. In case of an acute overdose, the patient should be given their stomach contents to vomit or have it removed with a tube, followed by supportive treatment. If the overdose is chronic, the dose should be reduced temporarily or taken every other day.
Orapred Novel Uses: Which Conditions Have a Clinical Trial Featuring Orapred?
115 active clinical trials are currently underway to assess the potential of Orapred to ameliorate Ocular Inflammation, Uveitis and Sympathetic Ophthalmia.Condition
Clinical Trials
Trial Phases
Uveitis
4 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 3
Giant Cell Arteritis
5 Actively Recruiting
Phase 3, Phase 1
Conjunctivitis
0 Actively Recruiting
Disease
0 Actively Recruiting
Urinary Tract Infection (UTI)
9 Actively Recruiting
Phase 1, Phase 3, Phase 4, Not Applicable
Swollen feet or ankles
5 Actively Recruiting
Phase 2, Not Applicable
Endocrine System Diseases
0 Actively Recruiting
Multiple Sclerosis
0 Actively Recruiting
Skin Diseases
1 Actively Recruiting
Phase 2
Gastroenteritis
4 Actively Recruiting
Not Applicable
Respiratory Diseases
5 Actively Recruiting
Not Applicable
Collagen Diseases
0 Actively Recruiting
Ophthalmia, Sympathetic
0 Actively Recruiting
Hypersensitivity
0 Actively Recruiting
Neoplastic Disease
1 Actively Recruiting
Phase 1
Orapred Reviews: What are patients saying about Orapred?
4.3Patient Review
6/11/2013 My daughter experienced some muscle soreness after taking this medication. It was bad enough that it was uncomfortable for her to even be touched.
4Patient Review
1/23/2010 I've been very pleased with this medication for my child's asthma. They don't become as hyperactive, which was a problem we experienced when using albuterol alone. The only downsides are that they sweat more and have increased appetite/thirst, but those are manageable compared to the benefits.
4Patient Review
5/31/2009 This cough medicine was really effective for my son.
3.7Patient Review
6/7/2011 Orapred has been effective at stopping my son's cough from croup, but he experiences severe side effects like crying and rubbing his eyes and ears obsessively. I'm glad it's only a 3 day course.
3.7Patient Review
11/29/2009 My child became more hyperactive and began to hallucinate about bugs after taking this medication. Even though it got rid of the poison ivy, I would not recommend it for children.
Patient Q&A Section about orapred
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Orapred a steroid?
"Orapred ODT is a medicine that contains the active ingredient prednisolone, which is a type of medicine known as a corticosteroid. Corticosteroids are medicines that are used to help reduce inflammation in the body."
Answered by AI
Is Orapred the same as prednisone?
"Prednisone and prednisolone are man-made steroids that are similar to cortisol, a hormone that your body produces naturally.
Brand names of prednisone include Prednisone Intensol and Rayos. Brand names of prednisolone include Flo-Pred, Pediapred, Orapred, and Orapred ODT. Prednisone and prednisolone are man-made steroids that are similar to cortisol. Both drugs are used to treat a variety of conditions, including allergies, autoimmune diseases, and skin conditions."
Answered by AI
What is Orapred used for?
"This drug is used to treat a variety of conditions that involve inflammation or an overactive immune system, including arthritis, blood disorders, skin and eye conditions, breathing problems, cancer, and severe allergies. It works by depressing the immune system, which decreases the inflammatory response and relieves symptoms such as pain, swelling, and allergic reactions."
Answered by AI