Pentoxil

Intermittent Claudication, Alcoholic Liver Diseases, Peripheral Arterial Disease + 1 more

Treatment

2 FDA approvals

20 Active Studies for Pentoxil

Treatment for

Intermittent Claudication

What is Pentoxil

PentoxifyllineThe Generic name of this drug

Treatment SummaryPentoxifylline (PTX) is a drug that helps to reduce the thickness of blood and has anti-inflammatory and anti-oxidant properties. It was first developed to treat intermittent claudication, a form of leg pain caused by poor circulation. PTX has been studied for its potential to treat many other conditions, like osteoradionecrosis, diabetic kidney disease, and inflammation from COVID-19. It has been available in Europe since 1972 and the United States since the late 1990s under the brand names TRENTAL and PENTOXIL. Generic versions of the drug are also available.

Trentalis the brand name

image of different drug pills on a surface

Pentoxil Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Trental

Pentoxifylline

1984

Approved as Treatment by the FDA

Pentoxifylline, also known as Trental, is approved by the FDA for 2 uses including Intermittent Claudication and Peripheral Arterial Disease .

Intermittent Claudication

Helps manage Intermittent Claudication

Peripheral Arterial Disease

Helps manage Peripheral Arterial Disease (PAD)

Effectiveness

How Pentoxil Affects PatientsPentoxifylline is a medicine related to theophylline and caffeine that is used to treat peripheral artery disease (PAD). It has anti-inflammatory, anti-oxidative, and blood-thinning properties. When taking pentoxifylline, people with cerebrovascular and coronary artery disease may be at risk of angina, arrhythmia, and low blood pressure. People taking warfarin should have their prothrombin times checked more frequently. Additionally, people with risk factors for bleeding like retinal bleeding, ulcers, and recent surgery should be monitored for signs of bleeding.

How Pentoxil works in the bodyPentoxifylline (PTX) helps treat peripheral arterial disease (PAD) by reducing blood viscosity, decreasing inflammation, and inhibiting white blood cell activation. It is thought to work by targeting a nuclear exporter protein and preventing molecules that suppress tumors from leaving cancerous cells. This keeps these tumor-suppressing molecules in the cell to stop it from reproducing. PTX also increases the response of certain receptors to adenosine and can raise intracellular cAMP levels. This leads to reduced inflammation, decreased pro-inflammatory molecules, increased anti-inflammatory molecules, and decreased production of f

When to interrupt dosage

The preferred measure of Pentoxil is contingent upon the diagnosed condition, including Venous Leg Ulcer (VLU), Alcoholic Liver Diseases and Peripheral Arterial Disease. The quantity of dosage is contingent upon the mode of delivery (e.g. Tablet, film coated, extended release or Gel - Topical) indicated in the table underneath.

Condition

Dosage

Administration

Peripheral Arterial Disease

400.0 mg, , 1.0 mg/mg, 0.02 mg/mg, 0.005 mg/mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Topical, Kit, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Topical, Gel, Gel - Topical

Venous Leg Ulcer (VLU)

400.0 mg, , 1.0 mg/mg, 0.02 mg/mg, 0.005 mg/mg

Intermittent Claudication

400.0 mg, , 1.0 mg/mg, 0.02 mg/mg, 0.005 mg/mg

Alcoholic Liver Diseases

400.0 mg, , 1.0 mg/mg, 0.02 mg/mg, 0.005 mg/mg

Warnings

Pentoxil has five contraindications. It should not be administered while suffering from the conditions in the following table.Pentoxil Contraindications

Condition

Risk Level

Notes

Food Intolerance

Do Not Combine

methylxanthine

Do Not Combine

Cerebral Hemorrhage

Do Not Combine

Retinal Hemorrhage

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Pentoxifylline may interact with Pulse Frequency

There are 20 known major drug interactions with Pentoxil.

Common Pentoxil Drug Interactions

Drug Name

Risk Level

Description

Abrocitinib

Major

The risk or severity of bleeding and thrombocytopenia can be increased when Pentoxifylline is combined with Abrocitinib.

Riociguat

Major

Pentoxifylline may increase the hypotensive activities of Riociguat.

Abacavir

Minor

Pentoxifylline may decrease the excretion rate of Abacavir which could result in a higher serum level.

Acebutolol

Minor

Pentoxifylline may increase the hypotensive activities of Acebutolol.

Aclidinium

Minor

Pentoxifylline may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Pentoxil Toxicity & Overdose RiskSigns of an overdose on pentoxifylline can appear 4-5 hours after ingestion, and include agitation, increased body temperature, low blood pressure, seizures, drowsiness, and loss of consciousness. To treat these symptoms, doctors may recommend maintaining proper respiration and blood pressure, and administering activated charcoal to absorb excess pentoxifylline. Even very high doses of the drug have been survived.

Pentoxil Novel Uses: Which Conditions Have a Clinical Trial Featuring Pentoxil?

68 active trials are currently evaluating the potential of Pentoxil to treat Venous Leg Ulcer (VLU), Intermittent Claudication and Alcoholic Liver Diseases.

Condition

Clinical Trials

Trial Phases

Intermittent Claudication

7 Actively Recruiting

Not Applicable, Phase 1, Phase 3, Phase 2

Alcoholic Liver Diseases

3 Actively Recruiting

Not Applicable, Phase 2

Peripheral Arterial Disease

41 Actively Recruiting

Not Applicable, Phase 3, Phase 2, Phase 1, Early Phase 1

Venous Leg Ulcer (VLU)

17 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 4

Patient Q&A Section about pentoxil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Pentoxil used for?

"This medication is used to improve the symptoms of a blood flow problem in the legs/arms called intermittent claudication. Intermittent claudication is when you have cramps or pain in your muscles during exercise, including walking. Pentoxifylline can help improve these symptoms by decreasing the muscle aching/pain/cramps during exercise."

Answered by AI

Is pentoxifylline a blood thinner?

"According to the research, pentoxifylline has the ability to thin the blood by increasing the deformability of red blood cells. This makes the cells easier to move and improves their rheological properties."

Answered by AI

Is pentoxifylline a blood pressure medication?

"The use of Trental (pentoxifylline) may increase the effectiveness of blood pressure medications. Close monitoring of blood pressure levels is necessary, and the dosage of blood pressure medication may need to be reduced."

Answered by AI

Clinical Trials for Pentoxil

Image of Clincial Research Site 92 in Jacksonville, United States.

Have you considered Pentoxil clinical trials? We made a collection of clinical trials featuring Pentoxil, we think they might fit your search criteria.

Image of Northwestern University Feinberg School of Medicine in Chicago, United States.

Exercise and Beetroot Juice for Peripheral Artery Disease

18+

All Sexes

Chicago, IL

This trial is looking at how exercise can help patients with peripheral artery disease (PAD). They will see if a 12-week exercise program can increase nitrite levels in the blood after 12 weeks compared

Phase 2

Recruiting

Behavior

Northwestern University Feinberg School of Medicine (+1 Sites)

Image of The Vascular Care Group in Darien, United States.

HIFU for Chronic Venous Insufficiency

18+

All Sexes

Darien, CT

This trial aims to see if a non-invasive device called Sonablate High Intensity Focused Ultrasound can safely treat patients with Chronic Venous Incompetence (CVI), which includes conditions

Recruiting

Has No Placebo

The Vascular Care GroupNaiem Nassiri, MD, FSVS, RPVISonablate

Verified

Image of GSK Investigational Site in Chandler, United States.

GSK4532990 for Alcohol-related Liver Disease

18 - 65

All Sexes

Chandler, AZ

"This trial aims to see if GSK4532990 is safe and effective for people with liver disease caused by alcohol."

GSK Investigational Site (+19 Sites)GlaxoSmithKline

Image of Three Rivers Wound and Hyperbaric Center in North Port, United States.

Porcine Placental Extracellular Matrix for Venous Leg Ulcers

18+

All Sexes

North Port, FL

This trial is testing whether using porcine placental extracellular matrix along with standard treatment is more effective in healing venous leg ulcers compared to standard treatment alone.

Recruiting

Has No Placebo

Three Rivers Wound and Hyperbaric CenterThomas E. Serena, MD FACSConvaTec Inc.

Have you considered Pentoxil clinical trials? We made a collection of clinical trials featuring Pentoxil, we think they might fit your search criteria.

Image of University of Oklahoma Health Sciences Center in Oklahoma City, United States.

Nicotinamide Riboside for Peripheral Arterial Disease

55 - 99

All Sexes

Oklahoma City, OK

This trial aimed to see if taking a daily 1g supplement of NR for 4 weeks can improve blood vessel function, brain blood flow, and cognitive function in older adults with peripheral artery disease.

Phase 1 & 2

Waitlist Available

Has No Placebo

University of Oklahoma Health Sciences Center

Image of ILD Research in Vista, United States.

PelloGraft + SanoGraft for Foot and Leg Ulcers

18+

All Sexes

Vista, CA

This trial aims to compare Pellograft for diabetic foot ulcers and Sanograft for venous leg ulcers to standard treatments. The study will look at wound healing outcomes like time to heal,

Recruiting

Has No Placebo

ILD ResearchSurgenex

Image of RHEACELL Clinical Trial Site in Miami, United States.

allo-APZ2-CVU for Venous Leg Ulcers

18+

All Sexes

Miami, FL

This trial aims to study whether a new medication called allo-APZ2-CVU, when applied on chronic wounds that do not heal with standard treatment, is effective and safe compared to a fake

Phase 3

Recruiting

Drug

RHEACELL Clinical Trial Site (+4 Sites)Anna MoessmerFGK Clinical Research GmbH

Image of SerenaGroup Omaha Research Center in Omaha, United States.

Multiple Treatments for Foot and Leg Ulcers

18 - 80

All Sexes

Omaha, NE

This trial aims to see if using multiple types of products along with standard treatment helps heal diabetic foot and venous leg ulcers better than standard treatment alone.

Recruiting

Has No Placebo

SerenaGroup Omaha Research Center (+3 Sites)Tomas Serena, MDIntegra LifeSciences Corporation

Have you considered Pentoxil clinical trials? We made a collection of clinical trials featuring Pentoxil, we think they might fit your search criteria.