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Vasodilator

Neurovascular Adaptations in Aging Women

Phase < 1
Recruiting
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Assigned female at birth (AFAB)
Aged 18-55 years
Must not have
Assigned male at birth (AMAB)
History of hysterectomy or oophorectomy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to learn more about how the blood vessels in older women change over time, focusing on the nervous system's role in these adaptations. "This trial aims to study how blood vessels change in

Who is the study for?
This trial is for aging women who are interested in participating in a study focused on understanding how their blood circulation and nervous system change with age. Specific eligibility criteria have not been provided.
What is being tested?
The trial is testing the effects of various substances, including Nitroprusside, Norepinephrine, Acetylcholine, Isoproterenol, and Estrogen on the sympathetic nervous system and blood circulation in aging women.
What are the potential side effects?
Potential side effects from the substances tested may include changes in blood pressure or heart rate (Nitroprusside), increased heart workload (Norepinephrine), flushing or low blood pressure (Acetylcholine), palpitations or tremors (Isoproterenol), and hormone-related effects from Estrogen.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I was assigned female at birth.
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I am between 18 and 55 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I was assigned male at birth.
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I have had a hysterectomy or oophorectomy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: WomenExperimental Treatment5 Interventions
Women will be 18-55 years of age
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Norepinephrine
2014
Completed Phase 4
~1780
Isoproterenol
2015
Completed Phase 3
~22740
Acetylcholine
2013
Completed Phase 2
~220
Nitroprusside
2013
Completed Phase 2
~310
Estrogen
2002
Completed Phase 4
~400

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
379 Previous Clinical Trials
628,430 Total Patients Enrolled
6 Trials studying Aging
243 Patients Enrolled for Aging
~43 spots leftby Jun 2027
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