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Fluoride Toothpaste

Fluoride Toothpaste + Mouthrinse for Preventing Tooth Decay

Phase < 1
Waitlist Available
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0 to 60 minutes after the interventions
Awards & highlights
No Placebo-Only Group

Summary

This trial will study the effects of fluoride toothpaste and mouthrinse on saliva in 20 adults from Ann Arbor, MI.

Who is the study for?
This trial is for adults over 18 with good oral and general health, normal saliva flow, no urgent dental needs, living in Ann Arbor, MI. They must understand the study protocol and commit to its full duration. It's not for those with poor health or low saliva production.
What is being tested?
The study tests fluoride availability in saliva after using two types of toothpaste (regular Crest Cavity Protection and prescription-strength Colgate PreviDent 5000+) alone or followed by Act Mint Fluoride Rinse. Participants will try all four combinations in a crossover design.
What are the potential side effects?
While specific side effects are not listed for this trial, typical reactions to fluoride products may include mild irritation inside the mouth or an upset stomach if swallowed.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0 to 60 minutes after the interventions
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 to 60 minutes after the interventions for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Area under the curve of fluoride bioavailability in saliva
Secondary study objectives
Maximum fluoride concentration in saliva

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Colgate PreviDent 5000+ followed by Act Mint Fluoride RinseExperimental Treatment1 Intervention
Colgate PreviDent 5000+ (5,000 ppm F) will be used to brush teeth, followed by a mouth rinse with Act Mint Fluoride Rinse (226 ppm)
Group II: Colgate PreviDent 5000+Active Control1 Intervention
Colgate PreviDent 5000+ (5,000 ppm F) will be used to brush teeth, followed by a mouth rinse with tap water
Group III: Crest Cavity ProtectionActive Control1 Intervention
Crest Cavity Protection toothpaste (1,100 ppm F) will be used to brush teeth, followed by a mouth rinse with tap water
Group IV: Crest Cavity Protection followed by Act Mint Fluoride RinseActive Control1 Intervention
Crest Cavity Protection toothpaste (1,100 ppm F) will be used to brush teeth, followed by a mouth rinse with Act Mint Fluoride Rinse (226 ppm)

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor
1,857 Previous Clinical Trials
6,437,664 Total Patients Enrolled

Media Library

Over-the-counter fluoride toothpaste (Fluoride Toothpaste) Clinical Trial Eligibility Overview. Trial Name: NCT05601154 — Phase < 1
Oral Cancers Research Study Groups: Colgate PreviDent 5000+, Colgate PreviDent 5000+ followed by Act Mint Fluoride Rinse, Crest Cavity Protection, Crest Cavity Protection followed by Act Mint Fluoride Rinse
Oral Cancers Clinical Trial 2023: Over-the-counter fluoride toothpaste Highlights & Side Effects. Trial Name: NCT05601154 — Phase < 1
Over-the-counter fluoride toothpaste (Fluoride Toothpaste) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05601154 — Phase < 1
~0 spots leftby Dec 2024
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