Multimodal Pain Relief for Tibial Plateau Fractures

Phase < 1

Waitlist Available

Led By Justin Haller, MD

Research Sponsored by University of Utah

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with isolated tibial plateau fractures treated by the investigators

Be older than 18 years old

Must not have

Non-English or Non-Spanish Speaking

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24-hours post-operative

Summary

This trial will test if multimodal analgesia (different types of pain relief) is more effective than just one type for treating tibial plateau fractures.

Who is the study for?

This trial is for English or Spanish speakers with isolated tibial plateau fractures treated by the study's investigators. It excludes those allergic to injection medications, with significant head trauma affecting consent ability, and patients with multiple traumatic injuries.

What is being tested?

The study tests the effectiveness of multimodal analgesia injections versus saline injections in reducing pain after tibial plateau fracture surgery. Effectiveness is measured by lower reported pain scores from patients.

What are the potential side effects?

While specific side effects are not listed, typical reactions might include discomfort at the injection site, potential allergic reactions if unknown allergies exist, and possible systemic effects depending on the drugs used in multimodal analgesia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have a tibial plateau fracture treated by the study's doctors.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I do not speak English or Spanish.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24-hours post-operative

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24-hours post-operative

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24-hours post-operative for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Visual Analog Scale (VAS) pain

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Multimodal injectionsExperimental Treatment1 Intervention

Superficial multimodal analgesia composition includes 5mg morphine, 500 micrograms epinephrine, and 4ml normal saline. Deep medial multimodal analgesia composition includes 2.5mg morphine, 40 micrograms clonidine, 15mg ketorolac, and 4ml normal saline.

Group II: Saline injectionPlacebo Group1 Intervention

Saline

0 / 2Eligibility criteria met