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Monoclonal Antibodies

Efficacy and Safety Study of AVB-S6-500 in Patients With Platinum-Resistant Recurrent Ovarian Cancer

Phase 1
Waitlist Available
Research Sponsored by Aravive, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 months

Summary

This trial tests a new drug, AVB-S6-500, combined with existing cancer treatment in patients with ovarian cancer that hasn't improved with other treatments. The goal is to see if this new combination works better than the existing treatments alone.

Eligible Conditions
  • Ovarian Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Anti-tumor activity of AVB-S6-500 in combination with PLD
Anti-tumor activity of AVB-S6-500 in combination with Pac
Incidence of Adverse Events (AEs)
Secondary study objectives
Anti-drug antibody (ADA) titers
CA-125 response rate
Disease control rate
+9 more

Trial Design

6Treatment groups
Experimental Treatment
Active Control
Group I: Phase 2: AVB-S6-500+PacExperimental Treatment2 Interventions
Group II: Phase 2: AVB-S6-500+PLDExperimental Treatment2 Interventions
Group III: Phase 1b: AVB-S6-500+PacExperimental Treatment2 Interventions
Group IV: Phase 1b: AVB-S6-500+PLDExperimental Treatment2 Interventions
Group V: Phase 2: Placebo+PacActive Control2 Interventions
Group VI: Phase 2: Placebo+PLDActive Control2 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
AVB-S6-500
2018
Completed Phase 1
~100
Paclitaxel (Pac)
2018
Completed Phase 1
~60
Pegylated liposomal doxorubicin (PLD)
2015
Completed Phase 3
~1060

Find a Location

Who is running the clinical trial?

Aravive, Inc.Lead Sponsor
8 Previous Clinical Trials
535 Total Patients Enrolled
Mary Jo BakerStudy DirectorAravive Biologics Inc
Amy FrankeStudy DirectorAravive, Inc.
3 Previous Clinical Trials
472 Total Patients Enrolled
~8 spots leftby Dec 2025
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