Enlicitide for Healthy Subjects

Recruiting in Palo Alto (17 mi)

Age: 18 - 65

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: Merck Sharp & Dohme LLC

No Placebo Group

Trial Summary

What is the purpose of this trial?The goal of the study is to learn what happens to enlicitide decanoate in a healthy person's body over time when taken on an empty stomach or with food. Researchers will compare what happens to enlicitide in a healthy person's body over time when enlicitide is taken with or without food. Enlicitide decanoate will be referred to as "enlicitide" throughout.

Eligibility Criteria

This trial is for healthy adults with a BMI between 18 and 32. It's designed to understand how the body processes enlicitide, a drug, when taken with or without food.

Inclusion Criteria

- Has body mass index (BMI) ≥18 kg/m\^2 and ≤32 kg/m\^2

Participant Groups

The study tests the effects of enlicitide on healthy individuals. Participants will take enlicitide either on an empty stomach or with food to see if there are any differences in how their bodies handle the drug.

4Treatment groups

Experimental Treatment

Group I: Enlicitide Treatment DExperimental Treatment1 Intervention

Participants receive single oral dose of enlicitide 2 hours after morning meal.

Group II: Enlicitide Treatment CExperimental Treatment1 Intervention

Participants receive single oral dose of enlicitide 3 hours after morning meal.

Group III: Enlicitide Treatment BExperimental Treatment1 Intervention

Participants receive single oral dose of enlicitide 4 hours after morning meal.

Group IV: Enlicitide Treatment AExperimental Treatment1 Intervention

Participants receive single oral dose of enlicitide after 8-hour overnight fast.