Your session is about to expire
← Back to Search
Small Molecule Inhibitor
PRT543 for Mantle Cell Lymphoma
Phase 1
Waitlist Available
Research Sponsored by Prelude Therapeutics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline through approximately 2 years
Awards & highlights
No Placebo-Only Group
Summary
This trial is testing a new drug called PRT543 in people with advanced cancers. The goal is to find the best way to use PRT543 safely in future treatments.
Eligible Conditions
- Mantle Cell Lymphoma
- Acute Myeloid Leukemia
- Leukemia
- Adenoid Cystic Carcinoma
- B-Cell Lymphoma
- Myelodysplastic Syndrome
- Myelofibrosis
- Solid Tumors
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline through approximately 2 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline through approximately 2 years
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
To describe dose limiting toxicities (DLT) of PRT543
To determine the maximally tolerated dose (MTD)
To determine the recommended phase 2 dose (RP2D) and schedule of PRT543
Secondary study objectives
To describe the adverse event profile and tolerability of PRT543
To determine the maximum observed plasma concentration (Cmax) of PRT543
To determine the time to reach maximum observed plasma concentration (Tmax) of PRT543
Other study objectives
To determine the area under the plasma concentration versus time curve (AUC) of PRT543
To determine the terminal elimination half-life (t1/2) of PRT543.
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: PRT543Experimental Treatment1 Intervention
PRT543 will be administered orally
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PRT543
2019
Completed Phase 1
~240
Find a Location
Who is running the clinical trial?
Prelude TherapeuticsLead Sponsor
10 Previous Clinical Trials
825 Total Patients Enrolled
Share this study with friends
Copy Link
Messenger