← Back to Search

Unknown

HPG1860 for Non-alcoholic Fatty Liver Disease (RISE Trial)

Phase 2
Waitlist Available
Led By Naim Alkhouri
Research Sponsored by Hepagene (Shanghai) Co., Ltd.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 week and 12 week

Summary

This trial is testing a new drug called HPG1860 on patients with a liver disease known as NASH. The drug aims to reduce liver damage and improve liver function. Different doses of the drug will be compared over a few months.

Eligible Conditions
  • Non-alcoholic Fatty Liver Disease (NAFLD)

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 week and 12 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 week and 12 week for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Safety and tolerability of treatment
Secondary study objectives
Change from baseline (CFB) in liver fat content (LFC) at 4 week
Percentage of subjects with ≥30% reduction in LFC from baseline
liver fat content

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: HPG1860 8 mgExperimental Treatment1 Intervention
20 subjects will be treated with HPG1860 5 mg once daily at a similar time with or without food.
Group II: HPG1860 5 mgExperimental Treatment1 Intervention
20 subjects will be treated with HPG1860 5 mg once daily at a similar time with or without food.
Group III: HPG1860 3 mgExperimental Treatment1 Intervention
20 subjects will be treated with HPG1860 3 mg once daily at a similar time with or without food.
Group IV: PlaceboPlacebo Group1 Intervention
20 subjects will be treated with Placebo once daily at a similar time with or without food.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
HPG1860
2019
Completed Phase 1
~60

Find a Location

Who is running the clinical trial?

Hepagene (Shanghai) Co., Ltd.Lead Sponsor
1 Previous Clinical Trials
56 Total Patients Enrolled
Naim AlkhouriPrincipal InvestigatorArizona Liver Health - Tucson
~23 spots leftby Nov 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top