Aerobic Exercise for Multiple Sclerosis

Palo Alto (17 mi)

Overseen byLindsey Wooliscroft, MD, MS

Age: 18 - 65

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Waitlist Available

Sponsor: Oregon Health and Science University

No Placebo Group

Approved in 3 jurisdictions

Trial Summary

What is the purpose of this trial?This is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).

Eligibility Criteria

This trial is for adults aged 18-64 with a confirmed diagnosis of multiple sclerosis (MS) who have internet access and can do virtual visits. They must not be very active, pregnant, or have had recent MS treatments or relapses. Changes in their MS medication within the last 6 months or certain medications affecting tests are also disqualifiers.

Inclusion Criteria

I am between 18 and 64 years old.

Exclusion Criteria

I have had a multiple sclerosis flare-up in the last 3 months.

I cannot use a bike or treadmill for health reasons.

I have a severe narrowing of my spinal canal.

Treatment Details

The study is testing if aerobic exercise like stationary cycling can help repair nerve insulation damage caused by MS. Participants will either join an education group as a control or engage in the exercise program to see if it makes a difference.

2Treatment groups

Experimental Treatment

Active Control

Group I: MS: CycleExperimental Treatment1 Intervention

Twenty-two participants in the clinical trial arm will be randomized to MS:Cycle: an aerobic exercise intervention on a stationary ergometer. Participants will exercise thrice weekly for 30 minutes with graded supervision for 24 weeks.

Group II: MS: Take ControlActive Control1 Intervention

Twenty-two participants in the clinical trial arm will be randomized to MS: Take Control (MSTC): a monthly, hour-long MS education control group led by a trained facilitator.

Aerobic exercise is already approved in United States, European Union, Canada for the following indications:

🇺🇸 Approved in United States as Aerobic Exercise for: