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Vitamin

Vitamin E in Aging Persons With Down Syndrome

Phase 3
Waitlist Available
Led By Arthur J Dalton, PhD
Research Sponsored by New York State Institute for Basic Research
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
All Individual Drugs Already Approved
Pivotal Trial

Summary

This trial aims to see if Vitamin E can slow down memory loss and cognitive decline in older people with Down syndrome. Vitamin E is known to protect brain cells from damage. The study includes older individuals with Down syndrome. Vitamin E has been tested for its potential to prevent or delay cognitive decline, with mixed results.

Eligible Conditions
  • Alzheimer's Disease
  • Down Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: 1Experimental Treatment2 Interventions
vitamin E plus multivitamin
Group II: 2Placebo Group2 Interventions
placebo with multivitamin
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
multivitamin
1999
Completed Phase 3
~430
Vitamin E
FDA approved

Find a Location

Who is running the clinical trial?

National Center for Complementary and Integrative Health (NCCIH)NIH
862 Previous Clinical Trials
673,751 Total Patients Enrolled
New York State Institute for Basic ResearchLead Sponsor
6 Previous Clinical Trials
614 Total Patients Enrolled
National Institute on Aging (NIA)NIH
1,794 Previous Clinical Trials
28,191,830 Total Patients Enrolled
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
2,061 Previous Clinical Trials
2,744,798 Total Patients Enrolled
Arthur J Dalton, PhDPrincipal InvestigatorNew York State Institute for Basic Research in Developmental Disabilities
Mary C Sano, PhDStudy DirectorIcahn School of Medicine at Mount Sinai
Paul S Aisen, MDStudy DirectorGeorgetown University
~15 spots leftby Dec 2025
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