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Celecoxib for Obsessive-Compulsive Disorder (ACE-OCD Trial)

Phase 2
Recruiting
Led By S. Evelyn Stewart, MD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks, 12 weeks
Awards & highlights
All Individual Drugs Already Approved
Approved for 10 Other Conditions

Summary

This trial will compare the effectiveness of celecoxib to placebo as an additional treatment for children and youth with moderate to severe OCD.

Eligible Conditions
  • Obsessive-Compulsive Disorder
  • Mental Health Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks, 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks, 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Children's Yale-Brown Obsessive-Compulsive Scale, 1st Edition (CY-BOCS-I)
Secondary study objectives
Mean Clinical Global Impression of Severity (CGI-S)
Mean Clinician Global Impression of Improvement (CGI-I)
Therapeutic procedure
+2 more

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: CelecoxibExperimental Treatment1 Intervention
Celecoxib 50 mg orally twice daily (if weight 10-25 kg) or 100 mg orally twice daily (if weight \> 25 kg) for 12 weeks. Used as adjunct to treatment-as-usual.
Group II: Placebo (microcrystalline cellulose)Placebo Group1 Intervention
Placebo capsules identical to celecoxib. One capsule orally twice daily for 12 weeks. Used as adjunct to treatment-as-usual.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Celecoxib
FDA approved

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,466 Previous Clinical Trials
2,485,376 Total Patients Enrolled
6 Trials studying Obsessive-Compulsive Disorder
753 Patients Enrolled for Obsessive-Compulsive Disorder
BC Children's Hospital Research InstituteOTHER
12 Previous Clinical Trials
2,257 Total Patients Enrolled
Obsessive Compulsive FoundationOTHER
6 Previous Clinical Trials
173 Total Patients Enrolled
6 Trials studying Obsessive-Compulsive Disorder
173 Patients Enrolled for Obsessive-Compulsive Disorder
~18 spots leftby Nov 2025
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