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Antibiotic

Amoxicillin for Antibiotic-Associated Diarrhea

Phase 4
Waitlist Available
Led By Yelina Alvarez, MD/PhD
Research Sponsored by Rockefeller University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights
Drug Has Already Been Approved
Pivotal Trial
No Placebo-Only Group

Summary

This trial will study how taking the antibiotic amoxicillin for a short period affects gut nerve and support cells in healthy people. Researchers want to see if changes in gut bacteria from the antibiotic lead to conditions like irritable bowel syndrome. The findings could help understand how antibiotics impact gut health.

Eligible Conditions
  • Antibiotic-Associated Diarrhea

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of colonic submucosal glia in the colon
Number of colonic submucosal neurons in the colon
Secondary study objectives
Changes in gene expression in submucosal glia
Changes in gene expression in submucosal neurons

Awards & Highlights

Drug Has Already Been Approved
The FDA has already approved this drug, and is just seeking more data.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Healthy ControlsExperimental Treatment1 Intervention
Healthy controls
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Amoxicillin Oral Capsule
2023
Completed Phase 4
~10

Find a Location

Who is running the clinical trial?

Rockefeller UniversityLead Sponsor
160 Previous Clinical Trials
16,517 Total Patients Enrolled
Yelina Alvarez, MD/PhDPrincipal InvestigatorRockefeller University

Media Library

Amoxicillin (Antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT05834036 — Phase 4
Antibiotic-Associated Diarrhea Research Study Groups: Healthy Controls
Antibiotic-Associated Diarrhea Clinical Trial 2023: Amoxicillin Highlights & Side Effects. Trial Name: NCT05834036 — Phase 4
Amoxicillin (Antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05834036 — Phase 4
~4 spots leftby Dec 2025