Ischemic Preconditioning for Intermittent Claudication

N/A

Waitlist Available

Research Sponsored by Medical College of Wisconsin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 weeks

Summary

This trial found that IPC may improve walking distance in people with intermittent claudication.

Eligible Conditions

Intermittent Claudication
Peripheral Arterial Disease
Vascular Ischemia
Peripheral Vascular Disease

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Peak walking time

Secondary study objectives

Claudication onset time

Muscle Fatigue

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Ischemic PreconditioningExperimental Treatment1 Intervention

A standard blood pressure cuff will be placed on the right or left thigh, depending on the affected side, to occlude blood flow. The cuff will be inflated to 225 mmHg to prevent blood flow. Each session will consist of 4 cycles of 5 minute IPC applications, followed by 5 minutes of reperfusion for a total of 35 minutes.

Group II: ControlPlacebo Group1 Intervention

The sham intervention protocol will be identical to the IPC protocol except blood flow to the affected leg is unchanged as cuff pressure will be raised to between the venous and diastolic pressures

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