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Behavioral Intervention
Cognitive Computerized Training for Cognitive Impairment (CCT Trial)
N/A
Recruiting
Led By Kirk R Daffner, MD
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Ages 25-65 years old
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights
No Placebo-Only Group
Summary
This trial tests a computer-based training program to help people with cognitive decline improve their memory and thinking skills by doing mental exercises regularly.
Who is the study for?
This trial is for adults aged 25-65 with attention and executive functioning issues or mild cognitive disorders from brain injuries at least a year old. Participants must speak English, be able to visit Brigham and Women's Hospital in Boston for assessments, have internet access, and provide an informant to report on their daily functioning.
What is being tested?
The study examines how well people with cognitive impairments due to brain injury can improve after doing intensive computerized cognitive training. It looks at what factors make the training more effective over a period of 12 months.
What are the potential side effects?
Since this trial involves non-invasive computerized cognitive exercises, there are no direct physical side effects like you'd expect from medication. However, participants may experience mental fatigue or frustration.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 25 and 65 years old.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Changes in BDNF Levels in blood and saliva
Changes in cognitive outcome measures
Secondary study objectives
Anxiety
Depression
Feelings about cognitive/thinking skills
+6 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Computerized Cognitive TrainingExperimental Treatment1 Intervention
See section of intervention/treatment for additional information.
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for Mild Cognitive Impairment (MCI), such as Computerized Cognitive Training Protocols, work by engaging participants in structured, computer-based exercises aimed at improving cognitive functions. These interventions enhance neuroplasticity, improve working memory, attention, and executive functions, and may delay the progression to dementia.
For MCI patients, these treatments are crucial as they help maintain cognitive abilities, improve daily functioning, and enhance overall quality of life.
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Who is running the clinical trial?
FujifilmIndustry Sponsor
2 Previous Clinical Trials
2,103 Total Patients Enrolled
Brigham and Women's HospitalLead Sponsor
1,666 Previous Clinical Trials
11,843,436 Total Patients Enrolled
Kirk R Daffner, MDPrincipal InvestigatorBrigham and Women's Hospital
Kim C Willment, PhDPrincipal InvestigatorBrigham and Women's Hospital