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Blueberry Supplementation for Cognitive Decline
N/A
Waitlist Available
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 24 weeks post intervention
Summary
This trial will test if consuming blueberry powder daily for several months can improve memory and cognitive function in older adults by using the brain-protective nutrients found in blueberries. Research has shown that blueberries, rich in polyphenolics, can reverse age-related cognitive deficits and improve neuronal function.
Who is the study for?
This trial is for adults aged 65-99 who can visit Brigham and Women's Hospital four times. It's not for those with blueberry allergies, recent major surgery, organ transplants, plans to move from Boston soon, dementia, severe cognitive decline or end-stage renal disease.
What is being tested?
The study tests if daily consumption of blueberry powder (20g) over 24 weeks improves memory and cognitive functions in older adults compared to a controlled powder without active ingredients.
What are the potential side effects?
Since the intervention involves blueberries which are generally safe, side effects might be minimal but could include potential allergic reactions or gastrointestinal discomfort.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline and 24 weeks post intervention
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 24 weeks post intervention
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in plasma concentration of neurofilament light (NFL) between baseline and 24 weeks
Change in plasma concentration of phosphorylated tau (pTau-181) between baseline and 24 weeks
Secondary study objectives
Change in cognitive battery test score between baseline and 24 weeks post intervention
Change in concentration of serum non-esterified fatty acids (NEFA) between baseline and 24 weeks
Change in plasma concentration of glial fibrillary acid protein (GFAB) between baseline and 24 weeks
Trial Design
2Treatment groups
Active Control
Placebo Group
Group I: Blueberry groupActive Control1 Intervention
Blueberry arm
Group II: Control groupPlacebo Group1 Intervention
Control arm
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for Traumatic Brain Injury (TBI) often focus on reducing inflammation and oxidative stress, which are key contributors to secondary brain damage. Antioxidants, such as those found in blueberry powder, help neutralize free radicals, thereby reducing oxidative stress and preventing further cellular damage.
Anti-inflammatory agents work by inhibiting inflammatory pathways, reducing swelling, and minimizing tissue damage. These mechanisms are crucial for TBI patients as they help to protect brain cells, improve recovery outcomes, and potentially enhance cognitive function.
Neuroprotective effect of Pycnogenol® following traumatic brain injury.
Neuroprotective effect of Pycnogenol® following traumatic brain injury.
Find a Location
Who is running the clinical trial?
Brigham and Women's HospitalLead Sponsor
1,670 Previous Clinical Trials
11,878,199 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have had an organ transplant.I have been diagnosed with a serious health condition such as dementia, severe kidney disease, or major cancer.I can travel to Brigham and Women's Hospital for 4 visits.I have not had, nor do I plan to have, major surgery within 3 months before or during the study.I am between 65 and 99 years old.
Research Study Groups:
This trial has the following groups:- Group 1: Control group
- Group 2: Blueberry group
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.