Sensorimotor Training + RTMS for Complex Regional Pain Syndrome

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: McMaster University

No Placebo Group

Trial Summary

What is the purpose of this trial?This study will investigate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) and a sensorimotor training task to treat symptoms of pain in patients with complex regional pain syndrome (CRPS). rTMS is a non-invasive technique that involves delivering magnetic pulses in rapid succession over the area of the brain that controls movement. The sensorimotor training task involves non-invasive nerve stimulation used to cue a participant to complete motor actions. The purpose of this study is to determine whether recruitment is feasible in this patient population and patients maintain adherence to the intervention. In addition, the investigators want to determine whether rTMS combined with sensorimotor training is an effective intervention to alleviate symptoms of pain in patients with CRPS.

Eligibility Criteria

This trial is for individuals with Complex Regional Pain Syndrome (CRPS) type 1 in one hand. Participants should not have moderate to severe chronic pain elsewhere, daily opioid use before CRPS diagnosis, contraindications to magnetic stimulation, or psychological issues affecting understanding.

Inclusion Criteria

You have been diagnosed with CRPS type 1 in one of your hands.

Exclusion Criteria

You have a history of moderate to severe chronic pain in other parts of your body.

You were taking opioids every day before being diagnosed with CRPS.

You have conditions that make it unsafe for you to receive transcranial magnetic stimulation.

+2 more

Participant Groups

The study tests if repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, combined with sensorimotor training can reduce pain in CRPS patients. It checks the feasibility of recruiting and maintaining patient adherence to this treatment.

3Treatment groups

Experimental Treatment

Active Control

Group I: Group C-Sensorimotor trainingExperimental Treatment1 Intervention

Participants will perform sensorimotor training intervention. Nerve stimulation will be applied to the second through fifth digits and the wrist of the affected limb to cue movement. This intervention will be performed approximately 4 days per week for 4 weeks. In addition, participants will experience their standard medical care.

Group II: Group B-rTMS and sensorimotor trainingExperimental Treatment2 Interventions

Repetitive transcranial magnetic stimulation (rTMS) will be delivered at 10 Hz, 2000 pulses targeting the hand representation of the left primary motor cortex. Immediately following rTMS, participants will perform sensorimotor training. Nerve stimulation will be applied to the second through fifth digits and the wrist of the affected limb to cue movement. This intervention will be performed approximately 4 days per week for 4 weeks. In addition, participants will experience their standard medical care.

Group III: Group A-ControlActive Control1 Intervention

Participants in this arm will not experience any intervention during a 4 week period of time. Participants will experience their standard medical care.

Repetitive transcranial magnetic stimulation is already approved in United States, European Union, Canada for the following indications:

🇺🇸 Approved in United States as rTMS for: