What side effects are associated with this type of intervention?

Magnesium supplementation, commonly used to enhance muscle function and energy production, can cause side effects such as gastrointestinal disturbances, including diarrhea, nausea, and abdominal cramping. High doses may lead to more severe symptoms like irregular heartbeat or low blood pressure. Other supplements aimed at improving exercise performance, such as creatine and omega-3 fatty acids, may also cause gastrointestinal issues, and in rare cases, creatine can lead to kidney damage if not used properly. Probiotics, used to modify gut microbiota, are generally safe but can sometimes cause bloating and gas.

What prior FDA approvals exist?

The FDA has approved various supplements and drugs aimed at enhancing exercise performance, focusing on muscle function and energy production. Creatine is one such supplement, known for its ability to improve muscle mass and strength. Beta-alanine, another approved supplement, helps buffer acid in muscles, thereby enhancing endurance. While magnesium supplementation is being studied for its potential benefits in muscle function and energy production, it is not specifically FDA-approved for exercise performance enhancement. Probiotics and prebiotics, which modify gut microbiota, are also being explored for their potential indirect benefits on exercise performance, although they are not yet FDA-approved for this specific use.

What other types of research exist?

Promising novel alternatives to magnesium supplementation for enhancing exercise performance in 2024 include creatine, which improves muscle function and energy production, omega-3 fatty acids, which support muscle health and reduce inflammation, and probiotics, which can positively modify gut microbiota and potentially enhance overall exercise performance.

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Mineral Supplement

Magnesium Supplements for Exercise Performance

N/A

Waitlist Available

Research Sponsored by Christopher Bell

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after 8 days of intervention

Summary

This trial is testing if taking magnesium supplements can help athletes perform better in exercise tests. The study focuses on endurance-trained adults because they are likely to benefit the most. Magnesium is important for many body functions, and the researchers want to see if it can also improve gut health and muscle function. Magnesium is involved in numerous processes that affect muscle function including oxygen uptake, energy production, and electrolyte balance.

Who is the study for?

This trial is for adults aged 18-40 who regularly exercise, specifically competitive cyclists with a 'Good' VO2max rating. It's not for those who've taken magnesium supplements recently, are pregnant or breastfeeding, can't do vigorous exercise, have kidney disease, or use certain medications like laxatives and heartburn treatments.

What is being tested?

The study is testing whether a short-term dietary supplement of magnesium (ReMag) can boost exercise performance, improve gut health by changing the microbiome, and enhance muscle function in mitochondria compared to a placebo.

What are the potential side effects?

While the trial doesn't list specific side effects of ReMag supplementation, common ones from magnesium intake include digestive issues like diarrhea and abdominal cramping. High doses might lead to more serious problems such as irregular heartbeat.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after 8 days of intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after 8 days of intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and after 8 days of intervention for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Calculation and ordination of B-diversity scores for all fecal samples to assess clustering

Comparison High-sensitivity C-reactive protein to placebo

Granulocyte-Macrophage Progenitor Cells

+20 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: ReMagExperimental Treatment1 Intervention

Liquid Lemon flavor drink containing 300 mg magnesium chloride (Regmag) consumed twice daily for 9 days

Group II: ReMag PlaceboPlacebo Group1 Intervention

Liquid Lemon flavor drink placebo comparator consumed twice daily for 9 days.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

ReMag

2021

N/A

~50

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Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Magnesium supplementation enhances exercise performance through several key mechanisms: it improves muscle function by aiding in muscle contraction and relaxation, supports energy production by participating in ATP synthesis, and modifies gut microbiota, which can influence overall health and recovery. These effects are crucial for exercise performance patients as they can lead to improved strength, endurance, and overall physical health, making magnesium a valuable supplement to consider in their fitness regimen.