High Flow Nasal Cannula vs Low Flow Oxygen for Respiratory Failure

N/A

Waitlist Available

Led By Ivan Pavlov, M.D.

Research Sponsored by Hôpital de Verdun

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Acute Hypercapnic respiratory failure with pH < 7.35 and pCO2 > 45 mmHg

Be older than 18 years old

Must not have

Respiratory or cardio-respiratory arrest

Hypercapnia secondary to a drug toxicity or non-pulmonary aetiology

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 hour, 6 hours, 24 hours, and daily until cessation of oxygen therapy, up to a maximum of 7 days

Awards & highlights

No Placebo-Only Group

Summary

This trial is looking at whether high flow nasal cannula (HFNC) can help people with respiratory problems who can't tolerate non-invasive ventilation (NIV).

Who is the study for?

This trial is for adults over 18 with non-severe hypercapnic respiratory failure, which means they have high levels of carbon dioxide in their blood and a lower than normal pH. It's not for those who can't read English or French, are pregnant, have certain severe conditions like shock or coma, drug-induced hypercapnia, or need immediate ventilation.

What is being tested?

The study compares two ways to give oxygen: High flow nasal cannula (HFNC) versus conventional low flow methods in patients with COPD experiencing high CO2 levels. The goal is to see if HFNC can correct gas exchange issues without needing mechanical ventilation.

What are the potential side effects?

Potential side effects may include discomfort from the nasal cannula or mask used for oxygen delivery. There could also be risks associated with receiving too much or too little oxygen such as dryness of the airways, nosebleeds, and breathlessness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have severe breathing problems with high CO2 levels and low pH in my blood.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have not had a respiratory or heart arrest.

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I have high carbon dioxide levels in my blood due to drug side effects or a non-lung related cause.

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I cannot read or understand French or English.

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I have high CO2 levels due to a severe asthma attack.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 hour, 6 hours, 24 hours, and daily until cessation of oxygen therapy, up to a maximum of 7 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 hour, 6 hours, 24 hours, and daily until cessation of oxygen therapy, up to a maximum of 7 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 hour, 6 hours, 24 hours, and daily until cessation of oxygen therapy, up to a maximum of 7 days for reporting.