← Back to Search

Prehabilitation for Liver Transplant Donors (PROPELLER Trial)

N/A

Recruiting

Research Sponsored by University Health Network, Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Must not have

Plan to be absent for more than 2 weeks of the intervention period

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to see if a prehab program can help living liver donors by improving their health before surgery. The program includes exercises, nutritional advice, and mental health support. The goal is to reduce pain and improve recovery after they donate their liver.

Who is the study for?

This trial is for English-speaking individuals scheduled for a living liver donation (LLD) with at least 28 days before their procedure. It's not suitable for those who'll be away for more than two weeks during the study or if their health status changes, making them ineligible to donate.

What is being tested?

The study is testing 'prehabilitation'—a preparatory care program—to see if it can improve recovery after liver donation. The goal is to check how feasible this approach is by looking at participant recruitment, adherence to the program, adverse events, and dropout rates.

What are the potential side effects?

Since this trial involves a prehabilitation program rather than medication, side effects may include discomfort or fatigue from physical exercises included in the regimen. However, specific side effects will depend on the details of the prehabilitation activities.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I will not be away for more than 2 weeks during the treatment period.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Feasibility Outcomes

Secondary study objectives

Hospital readmission

Post operative length of stay (LOS)

Surgical and post-operative complications

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: PrehabilitationExperimental Treatment1 Intervention

PREHAB participants will receive a multimodal intervention comprising of exercise, nutrition, and psycho/behavioural/educational support provided by an interprofessional prehab team comprising kinesiologists, dietitians, psychologists, and a previous LLD study partner. To facilitate overall compliance and appropriate adaptation to the home-based intervention components, participants will receive printed material, and a study coordinator will communicate weekly with patients to provide encouragement, monitor adherence, and clarify any questions or concerns.

Group II: Usual CareActive Control1 Intervention

Usual care participants will be instructed to resume typical lifestyle behaviours until the date of the surgery. To standardize exposure to publicly available resources, usual care participants will receive the 24-Hour Movement Guidelines for Adults,33 Canada's Food Guide,27 a list of stress management resources (website, apps, free reading material), and reference to the Smoker's Helpline.

0 / 1Eligibility criteria met