Brain Stimulation for Working Memory Issues

N/A

Recruiting

Research Sponsored by Bradley Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up theta-gamma coupling will be obtained immediately before (i.e., pre-itbs) and after itbs (i.e., post-itbs). there will be approximately 5 minutes between the pre and post eeg recordings. the change between pre-itbs and post-itbs is the outcome variable.

Awards & highlights

No Placebo-Only Group

Summary

This trial will use brain scans to see if non-invasive brain stimulation can improve working memory problems in adolescents, and help treat their mental health issues.

Who is the study for?

This trial is for adolescents aged 13-17 with an IQ over 80 and diagnosed ADHD, who struggle with working memory. They must be fluent in English, able to consent (with parental permission), and have a parent-reported BRIEF-2 Working Memory score above the norm. Exclusions include certain neurological conditions, metal implants affecting the brain or spinal cord, active psychosis or mania, current pregnancy, substance abuse within six months, and other specific medical criteria.

What is being tested?

The study tests whether non-invasive brain stimulation called Intermittent Theta Burst Stimulation can improve working memory in teens by targeting prefrontal and parietal brain regions. Participants will receive either the active treatment or a sham (placebo) version to compare effects on neural mechanisms underlying memory deficits.

What are the potential side effects?

While not explicitly listed here, side effects of Theta Burst Stimulation may include mild headaches or discomfort at the stimulation site; however individual experiences may vary.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ theta-gamma coupling will be obtained immediately before (i.e., pre-itbs) and after itbs (i.e., post-itbs). there will be approximately 5 minutes between the pre and post eeg recordings. the change between pre-itbs and post-itbs is the outcome variable.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~theta-gamma coupling will be obtained immediately before (i.e., pre-itbs) and after itbs (i.e., post-itbs). there will be approximately 5 minutes between the pre and post eeg recordings. the change between pre-itbs and post-itbs is the outcome variable.

This trial's timeline: 3 weeks for screening, Varies for treatment, and theta-gamma coupling will be obtained immediately before (i.e., pre-itbs) and after itbs (i.e., post-itbs). there will be approximately 5 minutes between the pre and post eeg recordings. the change between pre-itbs and post-itbs is the outcome variable. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Theta-Gamma Coupling After Sham iTBS

Change in Theta-Gamma Coupling after Active iTBS

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Sham intermittent Theta Burst StimulationExperimental Treatment1 Intervention

In a 2x2 factorial double-blind design, researchers will randomize a sample of adolescents with WM deficits to intermittent theta burst stimulation (iTBS) at the left dorsolateral prefrontal cortex (DLPFC) or inferior parietal lobule (IPL), based on each participant's structural brain MRI. Participants in both arms will complete an active iTBS session and a sham iTBS session. The primary outcome will be theta-gamma coupling during WM demands, as measured via electroencephalography (EEG) during a Sternberg spatial WM task (SWMT) immediately before and after iTBS.

Group II: Active intermittent Theta Burst StimulationExperimental Treatment1 Intervention

Do I qualify?Apply below to find out