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eBook + CHOICES Intervention for Sickle Cell Disease (CHOICES3 Trial)

N/A
Recruiting
Led By Diana Wilkie, PhD
Research Sponsored by University of Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
At-risk for having a child with SCD
18 to 45 years
Must not have
Physically unable to complete the study questionnaires or the intervention
Legally blind
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline up to 24 months

Summary

This trial will test whether nudges and tailored boosters can help people with sickle cell disease or thalassemia have a child free of their condition.

Who is the study for?
This trial is for adults aged 18-45 with Sickle Cell Disease (SCD) or Sickle Cell Trait (SCT), who can read and speak English, want to conceive within the next two years, and aim to have a child free of SCD. It's not open to those who've been in CHOICES studies before, are unable to complete study tasks, or cannot have children due to medical reasons.
What is being tested?
The CHOICES3 trial is testing a web-based program designed to help people with SCD/SCT make informed decisions about having children. Participants will use an online platform offering educational content and personalized support strategies aimed at reducing the risk of conceiving a child with SCD.
What are the potential side effects?
Since this intervention involves educational content delivered through an eBook rather than medication, there are no direct physical side effects expected from participating in this clinical trial.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am at risk of having a child with sickle cell disease.
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I am between 18 and 45 years old.
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I have been diagnosed with sickle cell disease or carry the sickle cell trait.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am unable to fill out study forms or participate in the study activities.
Select...
I am legally blind.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline up to 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to 24 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Sickle Cell Reproductive Health Knowledge

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: CHOICESExperimental Treatment1 Intervention
Experimental arm: receives the web-based reproductive education for individuals with sickle cell disease or sickle cell trait
Group II: eBook (electronic-Book)Placebo Group1 Intervention
Control arm with eBook education focused on sickle cell disease and sickle cell trait.

Find a Location

Who is running the clinical trial?

University of FloridaLead Sponsor
1,409 Previous Clinical Trials
766,953 Total Patients Enrolled
National Human Genome Research Institute (NHGRI)NIH
270 Previous Clinical Trials
293,563 Total Patients Enrolled
Diana Wilkie, PhDPrincipal InvestigatorUniversity of Florida

Media Library

CHOICES Clinical Trial Eligibility Overview. Trial Name: NCT05292781 — N/A
Sickle Cell Disease Research Study Groups: CHOICES, eBook (electronic-Book)
Sickle Cell Disease Clinical Trial 2023: CHOICES Highlights & Side Effects. Trial Name: NCT05292781 — N/A
CHOICES 2023 Treatment Timeline for Medical Study. Trial Name: NCT05292781 — N/A
~101 spots leftby Jun 2025
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