Spinal Cord Stimulation for Stroke Recovery

Recruiting in Palo Alto (17 mi)

Overseen ByLee Fisher, PhD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Lee Fisher, PhD

No Placebo Group

Trial Summary

What is the purpose of this trial?The goal of this study is to verify whether electrical stimulation of the cervical spinal cord can activate muscles of the arm and hand in people with hemiplegia following stroke. Participants will undergo a surgical procedure to implant a system which provides epidural electrical stimulation (EES) of the cervical spinal cord. Researchers will quantify the ability of EES to recruit arm and hand muscles and produce distinct kinematic movements. The implant will be removed after less than 30 days. Results of this study will provide the foundation for future studies evaluating the efficacy of a minimally-invasive neuro-technology that can be used in clinical neurorehabilitation programs to restore upper limb motor function in people with subcortical strokes, thereby increasing independence and quality of life.

Eligibility Criteria

This trial is for adults aged 21-70 who've had a stroke at least 6 months ago, resulting in arm weakness but not complete paralysis. They should be able to participate actively and not have severe diseases, cognitive issues, or be pregnant. They can't take certain medications or have implants that could interfere with the study.

Inclusion Criteria

I am between 21 and 70 years old.

Exclusion Criteria

I am mentally capable of understanding and signing a consent form.

I do not have any serious illness or cognitive issues that would prevent me from participating in the study.

I am taking medication for blood clots, muscle spasms, or seizures during the study.

Participant Groups

Researchers are testing if electrical stimulation of the spinal cord can help activate arm and hand muscles in stroke survivors with hemiplegia. Participants will get a temporary implant to deliver this stimulation and see if it improves their ability to move their limbs.

1Treatment groups

Experimental Treatment

Group I: Epidural electrical stimulation of the cervical spinal cordExperimental Treatment1 Intervention

Individuals with prior subcortical stroke and hemiparesis of the upper extremity.