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Neuromodulation

repetitive Trans Magnetic Stimulation for Opioid Use Disorder (TMS Trial)

N/A
Waitlist Available
Led By Aimee L. Mcrae-Clark, PharmD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 3 weeks
Awards & highlights

Summary

Despite the availability of opioid replacement therapies, many opioid use disordered Veterans are not able to remain abstinent. Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique with a consistent, rapidly expanding literature base reporting positive outcomes in substance using populations. This pilot application will investigate a novel multi-session rTMS paradigm to determine feasibility and tolerability of this intervention in opioid use disordered Veterans.

Eligible Conditions
  • Opioid Use Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 3 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 3 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Retention: Total Number of rTMS Sessions Completed
Tolerability: The Total Number of Treatment Emergent Adverse Events

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: rTMSExperimental Treatment1 Intervention
Participants will receive 18 sessions of active rTMS delivered at 120% rMT.
Group II: Sham TMSPlacebo Group1 Intervention
Participants will receive 18 sessions of sham rTMS delivered through an inactive coil.

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Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,647 Previous Clinical Trials
3,360,069 Total Patients Enrolled
Aimee L. Mcrae-Clark, PharmDPrincipal InvestigatorRalph H. Johnson VA Medical Center, Charleston, SC
1 Previous Clinical Trials
~0 spots leftby Sep 2025
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