Transcranial Magnetic Stimulation for Depression

Recruiting in Palo Alto (17 mi)

Age: 18 - 65

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Florida State University

No Placebo Group

Trial Summary

What is the purpose of this trial?The objective of this study is to examine the effect of intermittent theta-burst transcranial magnetic stimulation (iTBS) targeting the reward circuit.

Eligibility Criteria

This trial is for right-handed, English-speaking individuals who experience a lack of pleasure or interest in activities (anhedonia). They must not have metal implants in their head, brain conditions like tumors or multiple sclerosis, substance abuse issues within the last three months, severe mental health disorders that affect safety during the trial, high suicide risk, OCD, or be taking certain medications.

Participant Groups

The study is testing intermittent theta-burst transcranial magnetic stimulation (iTBS), which is a non-invasive procedure targeting the brain's reward circuit to see if it can improve feelings of pleasure and motivation.

2Treatment groups

Experimental Treatment

Active Control

Group I: MPFC-iTBSExperimental Treatment1 Intervention

Transcranial magnetic stimulation delivered to the medial prefrontal cortex. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds followed by 8 seconds of no stimulation repeated 20 times at 80% of resting motor threshold. Repeated daily for 5 consecutive days.

Group II: Inion-iTBSActive Control1 Intervention

Transcranial magnetic stimulation delivered to the inion. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds followed by 8 seconds of no stimulation repeated 20 times at 80% of resting motor threshold. Repeated daily for 5 consecutive days.