Gvoke Hypopen

Gastrointestinal tract structure, Hypoglycemia, Type 2 Diabetes + 1 more

Treatment

2 FDA approvals

0 Active Studies for Gvoke Hypopen

Treatment for

Gastrointestinal tract structure

What is Gvoke Hypopen

GlucagonThe Generic name of this drug

Treatment SummaryGlucagon is a hormone made up of 29 amino acids that is used to diagnose certain medical conditions and to treat severe low blood sugar. It works by stimulating the liver to release glucose into the bloodstream, which raises the blood sugar level. This drug was approved by the FDA in 1960 and is still commonly used today.

Glucagonis the brand name

image of different drug pills on a surface

Gvoke Hypopen Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Glucagon

1999

Approved as Treatment by the FDA

Glucagon, otherwise called Glucagon, is approved by the FDA for 2 uses including Hypoglycemia and Gastrointestinal tract structure .

Hypoglycemia

Gastrointestinal tract structure

Effectiveness

How Gvoke Hypopen Affects PatientsGlucagon is a drug used to help with certain medical imaging procedures and severe cases of low blood sugar. It works by activating receptors in the liver to release glucose, which raises the blood sugar level. Its effects are short-lived, and it can cause dangerously high blood sugar levels in people with diabetes.

How Gvoke Hypopen works in the bodyGlucagon binds to receptor cells in the body, triggering a chain reaction that increases cyclic AMP and protein kinase A. This causes the breakdown of glycogen, which releases energy, and relaxes the smooth muscles in the stomach, duodenum, small intestine, and colon.

When to interrupt dosage

The measure of Gvoke Hypopen is contingent upon the determined condition, including Gastrointestinal tract structure, Type 2 Diabetes and Type 2 Diabetes. The amount of dosage shifts, in line with the technique of administration (e.g. Intramuscular; Intravenous; Subcutaneous or Injection, powder, for solution - Intramuscular; Intravenous; Subcutaneous) featured in the table beneath.

Condition

Dosage

Administration

Gastrointestinal tract structure

, 1.0 mg/mL, 1.0 mg, 3.0 mg, 5.0 mg/mL, 10.0 mg/mL, 0.5 mg

, Kit, Intramuscular; Intravenous; Subcutaneous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous; Subcutaneous, Kit; Powder, for solution, Kit; Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Intramuscular, Kit; Powder, for solution - Intramuscular, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Kit - Intramuscular; Intravenous; Subcutaneous, Powder - Nasal, Nasal, Powder, Injection, solution, Subcutaneous, Injection, solution - Subcutaneous, Kit - Intramuscular; Intravenous

Hypoglycemia

, 1.0 mg/mL, 1.0 mg, 3.0 mg, 5.0 mg/mL, 10.0 mg/mL, 0.5 mg

Type 2 Diabetes

, 1.0 mg/mL, 1.0 mg, 3.0 mg, 5.0 mg/mL, 10.0 mg/mL, 0.5 mg

Type 2 Diabetes

, 1.0 mg/mL, 1.0 mg, 3.0 mg, 5.0 mg/mL, 10.0 mg/mL, 0.5 mg

Warnings

Gvoke Hypopen Contraindications

Condition

Risk Level

Notes

Glucagonoma

Do Not Combine

Insulinoma

Do Not Combine

Pheochromocytoma

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Glucagon may interact with Pulse Frequency

There are 20 known major drug interactions with Gvoke Hypopen.

Common Gvoke Hypopen Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Minor

The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Glucagon.

(S)-Warfarin

Minor

The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Glucagon.

4-hydroxycoumarin

Minor

The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Glucagon.

Acenocoumarol

Minor

The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Glucagon.

Clorindione

Minor

The therapeutic efficacy of Clorindione can be increased when used in combination with Glucagon.

Gvoke Hypopen Toxicity & Overdose RiskPeople who take too much glucagon may experience nausea, vomiting, difficulty digesting food, higher blood pressure and heart rate, and low potassium levels. To treat the overdose, medications like phentolamine may be given to control the blood pressure. Symptoms such as nausea, vomiting, and low potassium can also be treated with other therapies. The toxic dose of glucagon for mice is 300mg/kg and for rats is 38.6mg/kg.

image of a doctor in a lab doing drug, clinical research

Gvoke Hypopen Novel Uses: Which Conditions Have a Clinical Trial Featuring Gvoke Hypopen?

248 active investigations are presently looking into the possible benefits of Gvoke Hypopen in managing Type 2 Diabetes, Hypoglycemia and Type 2 Diabetes Mellitus.

Condition

Clinical Trials

Trial Phases

Type 2 Diabetes

88 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4

Type 2 Diabetes

168 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Hypoglycemia

0 Actively Recruiting

Gastrointestinal tract structure

0 Actively Recruiting

Gvoke Hypopen Reviews: What are patients saying about Gvoke Hypopen?

5Patient Review

10/14/2021

Gvoke Hypopen for person with diabetes mellitus at risk of hypoglycemia

This product is so easy to use and it really gives me peace of mind when my son has a low.

5Patient Review

8/2/2020

Gvoke Hypopen for Low Blood Sugar

I really appreciate how easy this is to use. The premixed solution is such a great idea and I'm glad it was invented. This is my favourite Glucagon injection by far.

5Patient Review

10/18/2021

Gvoke Hypopen for Low Blood Sugar

I really appreciate how easy this is to use. You just take off the cap and hold it against your skin for 5 seconds. insulin-using diabetics should definitely keep one of these on hand, because you never know when you'll need it.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about gvoke hypopen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for Gvoke to work?

"If you do not respond to the initial dose of GVOKE within 15 minutes, your caregiver may give you another dose, if available. Make sure to keep your healthcare provider updated each time you use GVOKE, as low blood sugar may occur again after receiving an injection. Your diabetes medication may need to be adjusted accordingly."

Answered by AI

When do you use Gvoke HypoPen?

"The GVOKE HypoPen is to be used for the treatment of severe hypoglycemia in pediatric and adult patients with diabetes who are at least 2 years old. Symptoms of severe hypoglycemia include loss of consciousness and seizures or convulsions."

Answered by AI

What is a Gvoke HypoPen?

"GVOKE is used to treat severe hypoglycemia in adults and children aged 2 years and above with diabetes. There is no known safety or efficacy in children under 2 years of age."

Answered by AI

Is Gvoke the same as glucagon?

"Gvoke contains the active drug glucagon. This hormone is found naturally in your body and it also comes as a medication. Glucagon works with your liver to make glucose (sugar) quickly available to your body and this raises your blood sugar level."

Answered by AI