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Dopamine Precursor

levodopa solution 2mg/ml for i.v. use for Tourette Syndrome (TSfMRI Trial)

Phase 1
Waitlist Available
Led By Kevin J Black, MD
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
All Individual Drugs Already Approved
Approved for 10 Other Conditions

Summary

Dr. Kevin J. Black at Washington University is conducting a study to learn whether we can use MRI scans to test dopamine function in the brain and to determine whether the brain performs memory tasks differently in Tourette Syndrome (TS). TS is a movement disorder characterized by vocal tics (sounds) and motor tics (movements). We will measure how and where brain activity changes using magnetic resonance imaging (MRI) scans during memory tasks and after taking levodopa. Levodopa is a drug commonly used for the treatment of Parkinson's disease (PD), a very different movement disorder.

Eligible Conditions
  • Tourette Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: levodopa solution 2mg/ml for i.v. useExperimental Treatment1 Intervention
levodopa solution in saline, given intravenously, dosed as per "final protocol" in Black et al 2003.
Group II: PlaceboPlacebo Group1 Intervention
normal saline i.v.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Levodopa
FDA approved

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,921 Previous Clinical Trials
2,742,810 Total Patients Enrolled
13 Trials studying Tourette Syndrome
3,290 Patients Enrolled for Tourette Syndrome
Washington University School of MedicineLead Sponsor
1,993 Previous Clinical Trials
2,296,033 Total Patients Enrolled
3 Trials studying Tourette Syndrome
164 Patients Enrolled for Tourette Syndrome
Kevin J Black, MDPrincipal InvestigatorWashington Universisty School of Medicine
3 Previous Clinical Trials
95 Total Patients Enrolled
1 Trials studying Tourette Syndrome
34 Patients Enrolled for Tourette Syndrome
~2 spots leftby Nov 2025
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