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Amino Acid

Low-tryptophan diet and L-tryptophan. for Diet Modification (Aryl-IMMUNE Trial)

N/A
Waitlist Available
Led By Premysl Bercik, MD, PhD
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Healthy volunteer between 18 and 75 years of age.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up three weeks.

Summary

This study evaluates the role of dietary L-tryptophan, an essential amino acid, in the activation of a specific cellular component: the aryl hydrocarbon receptor.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~three weeks.
This trial's timeline: 3 weeks for screening, Varies for treatment, and three weeks. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
AHR activation levels in stool and duodenal content.
Secondary study objectives
Bacterial and fungal microbiota composition in stool, duodenum and rectum/sigmoid biopsies.
Cytokines in serum.
Gastrointestinal symptoms
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Low-tryptophan diet and L-tryptophan.Experimental Treatment1 Intervention
Standardized low-tryptophan diet (500-1000 mg of L-tryptophan and 1800 kcal) + L-tryptophan supplements (3 g/day).
Group II: Low-tryptophan diet and placeboPlacebo Group1 Intervention
Standardized low-tryptophan diet (500-1000 mg of L-tryptophan and 1800 kcal) + placebo.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
L-tryptophan
2017
N/A
~20

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
917 Previous Clinical Trials
2,616,334 Total Patients Enrolled
National Research Agency, FranceOTHER
71 Previous Clinical Trials
58,734 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,389 Previous Clinical Trials
26,519,424 Total Patients Enrolled
~2 spots leftby Dec 2025
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