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Checkpoint Inhibitor

Tremelimumab for Bladder Cancer (Rideau Trial)

Phase 1 & 2
Waitlist Available
Led By Peter Black
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 months
Awards & highlights
No Placebo-Only Group

Summary

This trial will test whether a local injection of tremelimumab into the bladder wall, in combination with systemic administration of durvalumab, will stimulate an effective anti-tumour immune response with minimal clinical toxicity.

Eligible Conditions
  • Bladder Cancer
  • Malignant Tumor
  • Tremelimumab
  • Durvalumab

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 60 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of participants with grade 3 adverse events related to tremelimumab
Secondary study objectives
Complete pathological response
Other study objectives
Cytokine profiling
Immune cell analysis from whole blood sample
Cell-Free DNA

Side effects data

From 2019 Phase 2 trial • 33 Patients • NCT03007407
38%
Fatigue
21%
Diarrhea
17%
Nausea
17%
Fever
17%
Anorexia
17%
Maculopapular rash
17%
Pruritus
14%
Constipation
14%
Rash maculo-papular
10%
Anemia
10%
Abdominal pain
10%
Itching
7%
Hypothyroidism
7%
Non-cardiac chest pain
7%
Weight loss
7%
Cough
7%
Dry Skin
7%
Dehydration
100%
80%
60%
40%
20%
0%
Study treatment Arm
Durvalumab and Tremelimumab

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: TremelimumabExperimental Treatment1 Intervention
Patients who will receive local cystoscopic injection of tremelimumab into the bladder wall in combination with systemic administration of durvalumab
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tremelimumab
2017
Completed Phase 2
~3070

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,466 Previous Clinical Trials
2,485,456 Total Patients Enrolled
Peter BlackPrincipal InvestigatorUniversity of British Columbia

Media Library

Tremelimumab (Checkpoint Inhibitor) Clinical Trial Eligibility Overview. Trial Name: NCT05120622 — Phase 1 & 2
Bladder Cancer Research Study Groups: Tremelimumab
Bladder Cancer Clinical Trial 2023: Tremelimumab Highlights & Side Effects. Trial Name: NCT05120622 — Phase 1 & 2
Tremelimumab (Checkpoint Inhibitor) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05120622 — Phase 1 & 2
~0 spots leftby Nov 2025