Cabozantinib +/− Atezolizumab for Advanced Kidney Cancer
Trial Summary
The combination of Cabozantinib and Atezolizumab is unique because Cabozantinib is a multi-tyrosine kinase inhibitor that targets specific proteins involved in kidney cancer growth, while Atezolizumab is an immunotherapy drug that helps the immune system attack cancer cells. This combination offers a novel approach by combining targeted therapy with immunotherapy, potentially improving outcomes for patients with advanced kidney cancer.
12467Cabozantinib, when used with other drugs like nivolumab, has shown a manageable safety profile with common side effects such as diarrhea, fatigue, and skin reactions, which can be managed with medical care and dose adjustments. Atezolizumab, used for various cancers, has also been approved with a known safety profile. While specific data on the combination of Cabozantinib and Atezolizumab is not provided, both drugs have been used safely in humans for other conditions.
357910The trial requires that participants do not take certain medications, specifically strong CYP3A4 inhibitors and inducers, within 14 days before starting the trial and during the trial. If you are on these medications, you may need to stop or switch them, but the protocol does not specify about other medications.
Cabozantinib has been shown to help patients with advanced kidney cancer live longer without the disease getting worse compared to another drug, sunitinib. Atezolizumab, when combined with another drug, bevacizumab, has also shown benefits in patients with a specific type of kidney cancer, helping them live longer without disease progression and improving their ability to perform daily activities.
367811Eligibility Criteria
Adults with advanced papillary kidney cancer that has spread, who have not had certain treatments like PD-1/PD-L1 inhibitors in the past 6 months. They must be able to swallow pills, have no major health issues affecting trial participation, and agree to use effective contraception if of reproductive potential.Inclusion Criteria
Exclusion Criteria
Participant Groups
- Melanoma
- Hepatocellular carcinoma
- Small cell lung cancer
- Non-small cell lung cancer
- Urothelial carcinoma
- Melanoma
- Hepatocellular carcinoma
- Small cell lung cancer
- Non-small cell lung cancer
- Urothelial carcinoma