Methadone vs Morphine for Pain After Cesarean Delivery
Trial Summary
The trial information does not specify if you need to stop taking your current medications. However, if you have a history of chronic pain, opioid use, or certain health conditions, you may not be eligible to participate.
Research comparing oral methadone to intramuscular pethidine (another pain relief drug) suggests that methadone can be effective for managing pain after a cesarean section. This indicates that methadone may be a viable option for pain relief in this context.
12345Research indicates that methadone is effective and generally safe for pain relief after a cesarean delivery, with few side effects reported. However, caution is advised with high doses due to potential heart-related risks, and more studies are needed to fully understand its safety compared to other opioids.
46789Methadone, when used epidurally, is shown to be an effective and safe method for pain relief after cesarean delivery, with fewer side effects compared to morphine. It provides longer-lasting pain relief, which can be beneficial for managing postoperative pain.
46101112Eligibility Criteria
This trial is for English-speaking women over 18 years old scheduled for a cesarean delivery. It's not suitable for those with opioid intolerance, severe obesity (BMI >50), heart issues (QTc >440ms), high-risk health status (ASA IV, V), chronic pain or substance use disorders, liver/kidney failure, certain respiratory conditions, pre-eclampsia in current pregnancy, depression treated with multiple medications, or if general anesthesia becomes necessary.Inclusion Criteria
Exclusion Criteria