Hydroxyapatite Toothpaste for Molar Incisor Hypomineralization

N/A

Waitlist Available

Led By Bennett T Amaechi, BDS, MS, PhD

Research Sponsored by The University of Texas Health Science Center at San Antonio

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to 2 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial tests two types of toothpaste to see which one better repairs damaged teeth. Participants will use either a mineral-adding toothpaste or a decay-resistant toothpaste. The mineral-adding toothpaste helps by adding minerals back into the teeth, while the decay-resistant toothpaste makes the teeth more resistant to decay. The mineral-adding toothpaste has been studied for its potential to prevent root damage and reduce tooth sensitivity.

Who is the study for?

This trial is for adults aged 18-60 with good general health, normal saliva flow, and at least 20 natural teeth. They must be willing to use only the assigned toothpaste for oral hygiene during the study and wear an intra-oral appliance all day. People with orthodontic retainers, impaired salivary function, recent antibiotic use or participation in other clinical studies are excluded.

What is being tested?

The study compares two types of toothpaste: one with hydroxyapatite (HAP) and another with sodium fluoride. It aims to see which better remineralizes teeth affected by Molar Incisor Hypomineralization (MIH). Participants will use these products on donor teeth placed in an oral appliance.

What are the potential side effects?

There may not be significant side effects as both hydroxyapatite and sodium fluoride toothpastes are generally considered safe for dental use. However, some individuals might experience mild irritation or allergic reactions if they have sensitivities to specific ingredients in the toothpaste.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to 2 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to 2 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 2 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Mineral Density (MD) of Tooth

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: MIH-bearing tooth block exposed to HAP toothpasteExperimental Treatment1 Intervention

A block of molar incisor hypomineralization (MIH) is mounted in an oral appliance and fitted in the subject for testing with the HAP toothpaste

Group II: MIH-bearing block exposed to Sodium Fluoride toothpasteExperimental Treatment1 Intervention

A block of molar incisor hypomineralization (MIH) is mounted in an oral appliance and fitted in the subject for testing with the sodium fluoride toothpaste

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