Genetic Testing Interventions for Cancer Risk (MiGHT Trial)

Recruiting in Palo Alto (17 mi)

Elena M. Stoffel | Faculty | Michigan ...

Overseen ByElena Stoffel, MD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Michigan Rogel Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?The primary purpose of this study is to compare three interventions, two experimental and one standard of care (usual care), to see if the experimental interventions will increase the likelihood of a participant obtaining guideline-concordant genetic testing. Eligible participants will be randomized (assigned) to one of the following interventions: 1) Virtual genetics navigator, a mobile-optimized website, designed by the investigators, that delivers tailored messages and content; 2) two motivational interviewing (MI) telephone calls delivered by trained genetics health coaches; or 3) usual care.

Eligibility Criteria

This trial is for English-speaking adults in Michigan with a history of certain cancers (breast, ovarian, endometrial, colorectal, prostate or pancreatic) who haven't had genetic testing yet. They must have internet access and meet specific clinical criteria for genetic evaluation based on their cancer type and family history.

Participant Groups

The study compares three methods to see if they increase the likelihood of getting recommended genetic testing: a virtual genetics navigator website with tailored content; motivational interviewing calls by trained coaches; or usual care without these interventions.

3Treatment groups

Experimental Treatment

Active Control

Group I: Arm 3 - Motivational interviewing (MI)Experimental Treatment1 Intervention

Participants receive up to 2 phone calls from trained genetics health coaches who provide information about genetic testing and use motivational interviewing to encourage participants to seek out clinical genetic testing.

Group II: Arm 2 - Virtual genetics navigatorExperimental Treatment1 Intervention

Participants receive access to an online genetics tool, the virtual genetics navigator, to help learn why and how to seek out genetic testing for hereditary cancer syndromes.

Group III: Arm 1 - Usual care (UC)Active Control1 Intervention

Participants are provided with a link to the Michigan Department of Health and Human Services (MDHHS) informational website and are instructed to follow up with their oncology provider about genetic testing.